ArticleMagnetic resonance in medicine2015
Magnetization transfer from inhomogeneously broadened lines: A potential marker for myelin.
Article in Magnetic resonance in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Spatiotemporal white-matter development across early childhood.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- SNR-Efficient Inhomogeneous Magnetization Transfer (ihMT) for Clinical Applications at 7 T.Magnetic resonance in medicine · 2026Article
- Dipolar Order Mapping Based on Spin-Lock Magnetic Resonance Imaging.NMR in biomedicine · 2026Article
- Reducing Inhomogeneous MT (ihMT) Acquisition Time Using Frequency Alternation at Low Duty Cycle for Single Offset (FALSO) MT Preparations.Magnetic resonance in medicine · 2026Article
- Structural Characterization of Cardiac Free-Running Purkinje Fibers Using Inhomogeneous Magnetization Transfer (ihMT): A Proof of Concept MRI-Histology Approach.NMR in biomedicine · 2026Article
- Multi-contrast dual-resolution UTE for myelin fraction mapping and structural imaging.Magma (New York, N.Y.) · 2026Article
- Article
- Interpretation of inhomogeneous magnetization transfer in myelin water using a four-pool model with dipolar reservoirs.Magnetic resonance in medicine · 2025Article
- Multiparametric MRI Can Detect Enhanced Myelination in the Ex Vivo Gli1NMR in biomedicine · 2025Article
- Decoding Brain Development and Aging: Pioneering Insights From MRI Techniques.Investigative radiology · 2025Review
- An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter.Scientific reports · 2025Article
- So You Want to Image Myelin Using MRI: Magnetic Susceptibility Source Separation for Myelin Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Review
- The contribution of preclinical magnetic resonance imaging and spectroscopy to Huntington's disease.Frontiers in aging neuroscience · 2024Review
- Inhomogeneous magnetization transfer (ihMT) imaging reveals variable recovery profiles of active MS lesions according to size and localization.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- 3D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice.Frontiers in neuroimaging · 2024Article
- Quantitative magnetic resonance mapping of the myelin bilayer reflects pathology in multiple sclerosis brain tissue.Science advances · 2023Article
- High-frequency longitudinal white matter diffusion- and myelin-based MRI database: Reliability and variability.Human brain mapping · 2023Article
- Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status.Brain : a journal of neurology · 2023Review
- Applications of advanced diffusion MRI in early brain development: a comprehensive review.Brain structure & function · 2023Review
1 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
purposeTo characterize a new approach to magnetization transfer (MT) imaging with improved specificity for myelinated tissues relative to conventional MT.
methodsMagnetization transfer preparation sequences were implemented with all radiofrequency power centered on a single frequency and also with power evenly divided between positive and negative frequencies. Dual frequency saturation was achieved both with short, alternating frequency pulses and with sinusoidal modulation of continuous irradiation. Images following preparation were acquired with a single shot fast spin echo sequence. Single and dual frequency preparation should achieve similar saturation of molecules except for those with inhomogenously broadened lines. Inhomogenous MT (IHMT) images were generated by subtraction of dual from single frequency prepared images. IHMT imaging was performed with different power and frequency in the brains of normal volunteers.
resultsThe IHMT method demonstrated a greater white/gray matter ratio than conventional MT and virtual elimination of signal in scalp and other unmyelinated tissues. IHMT exceeded 5% of the fully relaxed magnetization in white matter. A broad frequency spectrum and signs of axonal angular dependence at high frequency were observed that are consistent with dipolar broadening.
conclusionIHMT shows promise for myelin-specific imaging. Further study of physical mechanisms and diagnostic sensitivity are merited.
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