ArticleInternational journal of oncology2014
The metastasis suppressor SOX11 is an independent prognostic factor for improved survival in gastric cancer.
Article in International journal of oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Effects of transcription factorAnnals of surgical treatment and research · 2024Article
- Clinical Significance of SOX10 Expression in Human Pathology.Current issues in molecular biology · 2023Review
- Systematic Investigation of the Multifaceted Role ofCancers · 2022Article
- LINC01296 promotes neuroblastoma tumorigenesis via the NCL-SOX11 regulatory complex.Molecular therapy oncolytics · 2022Article
- MiR-937-3p promotes metastasis and angiogenesis and is activated by MYC in lung adenocarcinoma.Cancer cell international · 2022Article
- SOX11 is a sensitive and specific marker for pulmonary high-grade neuroendocrine tumors.Diagnostic pathology · 2022Article
- Increased Progastrin-Releasing Peptide Expression is Associated with Progression in Gastric Cancer Patients.Yonsei medical journal · 2020Article
- SOX11: friend or foe in tumor prevention and carcinogenesis?Therapeutic advances in medical oncology · 2019Review
- lncRNA MEG3 inhibits the growth of hepatocellular carcinoma cells by sponging miR-9-5p to upregulate SOX11.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Overexpression miR-211-5p hinders the proliferation, migration, and invasion of thyroid tumor cells by downregulating SOX11.Journal of clinical laboratory analysis · 2018Article
- Aberrant methylation ofJournal of Cancer · 2018Article
- Melanoma differentiation-associated gene-7 suppresses human gastric cancer cell invasion and migration.Oncology letters · 2017Article
- The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression.Oncotarget · 2016Article
- Identification of potential biomarkers to differentially diagnose solid pseudopapillary tumors and pancreatic malignancies via a gene regulatory network.Journal of translational medicine · 2015Article
- Aberrant SOX11 promoter methylation is associated with poor prognosis in gastric cancer.Cellular oncology (Dordrecht, Netherlands) · 2015Article
- Characterization of differentially expressed genes involved in pathways associated with gastric cancer.PloS one · 2015Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
SOX11 is involved in gastrulation and in malignant diseases. The aim of this study was to investigate the role of SOX11 in gastric cancer and its expression pattern and clinical significance. SOX11 overexpression cell model was used to examine in vitro and in vivo the role of SOX11 in cell growth and metastasis. Cell cycle analysis and Annexin V/PI double staining were used to investigate the effect of SOX11 on cell cycle progression and apoptosis. The expression of SOX11 in human gastric cancer was examined by immunohistochemistry. The correlation of SOX11 expression with clinicopathological characteristics and survival of patients was analyzed by Pearson's χ(2) and Kaplan-Meier analyses, respectively. Cox's proportional hazard model was employed in multivariate analysis. SOX11 overexpression did not inhibit cell growth but strongly suppressed cell migration/invasion in vitro and in vivo. We found a significant correlation between high SOX11 protein levels and Lauren's classification (intestinal type), differentiation status (high and medium), and early TNM stage. SOX11 is an independent prognostic factor for improved survival in gastric cancer patients. SOX11 was a potential tumor-suppressor and an independent positive prognostic factor in gastric cancer patients with less advanced clinicopathological features.
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