ArticleScientific reports2014
Ancient pathogen DNA in archaeological samples detected with a Microbial Detection Array.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A minimal hybridization capture approach for the parallel enrichment and cost-effective detection of ancient human pathogens.iScience · 2026Article
- Big Epidemiology: The Birth, Life, Death, and Resurgence of Diseases on a Global Timescale.Epidemiologia (Basel, Switzerland) · 2024Review
- The Recovery, Interpretation and Use of Ancient Pathogen Genomes.Current biology : CB · 2020Review
- Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice.Scientific reports · 2020Article
- Mosquito-Borne Viruses and Insect-Specific Viruses Revealed in Field-Collected Mosquitoes by a Monitoring Tool Adapted from a Microbial Detection Array.Applied and environmental microbiology · 2019Article
- Ancient pathogen genomics as an emerging tool for infectious disease research.Nature reviews. Genetics · 2019Review
- Axiom Microbiome Array, the next generation microarray for high-throughput pathogen and microbiome analysis.PloS one · 2019Article
- Article
- Transmission, Evolution, and Endogenization: Lessons Learned from Recent Retroviral Invasions.Microbiology and molecular biology reviews : MMBR · 2018Review
- Ancient oncogenesis, infection and human evolution.Evolutionary applications · 2017Review
- Environmental Microbial Forensics and Archaeology of Past Pandemics.Microbiology spectrum · 2017Review
- Insights into human evolution from ancient and contemporary microbiome studies.Current opinion in genetics & development · 2016Review
- Targeted amplification for enhanced detection of biothreat agents by next-generation sequencing.BMC research notes · 2015Article
- Reconstructing ancient genomes and epigenomes.Nature reviews. Genetics · 2015Review
- Ancient human microbiomes.Journal of human evolution · 2015Article
- Parallel detection of ancient pathogens via array-based DNA capture.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- The microbial detection array for detection of emerging viruses in clinical samples--a useful panmicrobial diagnostic tool.PloS one · 2014Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ancient human remains of paleopathological interest typically contain highly degraded DNA in which pathogenic taxa are often minority components, making sequence-based metagenomic characterization costly. Microarrays may hold a potential solution to these challenges, offering a rapid, affordable, and highly informative snapshot of microbial diversity in complex samples without the lengthy analysis and/or high cost associated with high-throughput sequencing. Their versatility is well established for modern clinical specimens, but they have yet to be applied to ancient remains. Here we report bacterial profiles of archaeological and historical human remains using the Lawrence Livermore Microbial Detection Array (LLMDA). The array successfully identified previously-verified bacterial human pathogens, including Vibrio cholerae (cholera) in a 19th century intestinal specimen and Yersinia pestis ("Black Death" plague) in a medieval tooth, which represented only minute fractions (0.03% and 0.08% alignable high-throughput shotgun sequencing reads) of their respective DNA content. This demonstrates that the LLMDA can identify primary and/or co-infecting bacterial pathogens in ancient samples, thereby serving as a rapid and inexpensive paleopathological screening tool to study health across both space and time.
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