ArticlePloS one2014
Regulators of human white adipose browning: evidence for sympathetic control and sexual dimorphic responses to sprint interval training.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Chronic Exercise Training and Circulating Irisin in Adults: A Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2015Pooled it
- Effect of exercise on Fibroblast Growth Factor 21 levels in healthy males and females.PloS one · 2025Trial
- Trial
- Housing temperature influences exercise-induced glucose regulation and expression of exerkines in mice.Experimental physiology · 2025Article
- Irisin Concentrations in Children and Adolescent Cancer Survivors and Their Relation to Metabolic, Bone, and Reproductive Profile: A Pilot Case-Control Study.Journal of clinical medicine · 2025Article
- The hypothalamic estrogen receptor α pathway is involved in high-intensity interval training-induced visceral fat loss in premenopausal rats.Lipids in health and disease · 2025Article
- The time course of irisin release after an acute exercise: relevant implications for health and future experimental designs.European journal of translational myology · 2024Article
- The Effects of Different Types of Exercise on Circulating Irisin Levels in Healthy Individuals and in People With Overweight, Metabolic Syndrome and Type 2 Diabetes.Physiological research · 2022Review
- Review
- Sympathetic nerve-adipocyte interactions in response to acute stress.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Effect of BMI on the Thermogenic Response to Cold Exposure and Associated Changes in Metabolism and Browning Markers in Adult Humans.Obesity facts · 2022Article
- Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential.Frontiers in endocrinology · 2021Article
- Irisin Is Correlated with Blood Pressure in Obstructive Sleep Apnea Patients.International journal of hypertension · 2021Article
- The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity.International journal of endocrinology · 2021Review
- The Role of Irisin in Exercise-Mediated Bone Health.Frontiers in cell and developmental biology · 2021Review
- Sex differences on adipose tissue remodeling: from molecular mechanisms to therapeutic interventions.Journal of molecular medicine (Berlin, Germany) · 2020Review
- Association of Irisin Serum Concentration and Muscle Strength in Normal-Weight and Overweight Young Women.Frontiers in endocrinology · 2019Article
- Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions.International journal of endocrinology · 2018Review
- Exercise Induces White Adipose Tissue Browning Across the Weight Spectrum in Humans.Frontiers in physiology · 2018Article
- Variations in leptin, nesfatin-1 and irisin levels induced by aerobic exercise in young trained and untrained male subjects.Biology of sport · 2017Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The conversion of white adipose to the highly thermogenic beige adipose tissue has been proposed as a potential strategy to counter the unfavorable consequences of obesity. Three regulators of this conversion have recently emerged but information regarding their control is limited, and contradictory. We present two studies examining the control of these regulators. Study 1: In 10 young men, the plasma concentrations of irisin and fibroblast growth factor 21 (FGF21) were determined prior to and during activation of the sympathetic nervous system via hypoxic gas breathing (FIO2 = 0.11). The measurements were performed twice, once with and once without prior/concurrent sympathetic inhibition via transdermal clonidine administration. FGF21 was unaffected by basal sympathetic inhibition (338±113 vs. 295±80 pg/mL; P = 0.43; mean±SE), but was increased during hypoxia mediated sympathetic activation (368±135); this response was abrogated (P = 0.035) with clonidine (269±93). Irisin was unaffected by sympathetic inhibition and/or hypoxia (P>0.21). Study 2: The plasma concentration of irisin and FGF21, and the skeletal muscle protein content of fibronectin type III domain containing 5 (FNDC5) was determined in 19 young adults prior to and following three weeks of sprint interval training (SIT). SIT decreased FGF21 (338±78 vs. 251±36; P = 0.046) but did not affect FNDC5 (P = 0.79). Irisin was decreased in males (127±18 vs. 90±23 ng/mL; P = 0.045) and increased in females (139±14 vs. 170±18). Collectively, these data suggest a potential regulatory role of acute sympathetic activation pertaining to the browning of white adipose; further, there appears to be a sexual dimorphic response of irisin to SIT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.