ArticlePLoS pathogens2014
Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.
Article in PLoS pathogens, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV
Clinical and Immunologic Monitoring of Patients With Known or Suspected HIV Infection
Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
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- Immune-Related Protein Interaction Network in Severe COVID-19 Patients toward the Identification of Key Proteins and Drug Repurposing.Biomolecules · 2022Article
- IFN-α blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health.JCI insight · 2022Article
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- Hsa-miR-31 Governs T-Cell Homeostasis in HIV ProtectionFrontiers in immunology · 2021Article
- Transcriptional profiling of leukocytes in critically ill COVID19 patients: implications for interferon response and coagulation.Intensive care medicine experimental · 2020Article
- An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics.Emerging microbes & infections · 2020Article
- Dynamics of Transforming Growth Factor (TGF)-β Superfamily Cytokine Induction During HIV-1 Infection Are Distinct From Other Innate Cytokines.Frontiers in immunology · 2020Article
- HIV control: Is getting there the same as staying there?PLoS pathogens · 2018Review
- Reduced Chronic Lymphocyte Activation following Interferon Alpha Blockade during the Acute Phase of Simian Immunodeficiency Virus Infection in Rhesus Macaques.Journal of virology · 2018Article
- miRNA-31 regulates the CD8 T cell response to type I IFNs during chronic infection.Cellular & molecular immunology · 2018Article
- Sustained IFN-I Expression during Established Persistent Viral Infection: A "Bad Seed" for Protective Immunity.Viruses · 2017Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
HIV infection and the associated chronic immune activation alter T cell homeostasis leading to CD4 T cell depletion and CD8 T cell expansion. The mechanisms behind these outcomes are not totally defined and only partially explained by the direct cytopathic effect of the virus. In this manuscript, we addressed the impact of lymphopenia and chronic exposure to IFN-α on T cell homeostasis. In a lymphopenic murine model, this interaction led to decreased CD4 counts and CD8 T cell expansion in association with an increase in the Signal Transducer and Activator of Transcription 1 (STAT1) levels resulting in enhanced CD4 T cell responsiveness to IFN-α. Thus, in the setting of HIV infection, chronic stimulation of this pathway could be detrimental for CD4 T cell homeostasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.