Evidence map›Paper›PMID 24603425›Full record

ArticleEye (London, England)2014

Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma.

J H Kang, S J Loomis, B L Yaspan, J C Bailey, R N Weinreb, R K Lee, P R Lichter, D L Budenz, Y Liu, T Realini and 26 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Caveolins and caveolae in ocular physiology and pathophysiology.Progress in retinal and eye research · 2017
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Big data in visual field testing for glaucoma.Taiwan journal of ophthalmology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 18 institutions in 1 country.

J H KangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
S J LoomisDepartment of Ophthalmology, Mass Eye and Ear, Boston, MA, USA.
B L YaspanGenentech Inc., San Francisco, CA, USA.
J C BaileyCenter for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN, USA.
R N WeinrebDepartment of Ophthalmology and Hamilton Glaucoma Center, University of California at San Diego, San Diego, CA, USA.
R K LeeBascom Palmer Eye Institute and Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
P R LichterDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.
D L BudenzDepartment of Ophthalmology, University of North Carolina, Chapel Hill, NC, USA.
Y Liu1] Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA [2] Department of Medicine, Duke University Medical Center, Durham, NC, USA.
T RealiniDepartment of Ophthalmology, West Virginia University Eye Institute, Morgantown, WV, USA.
D GaasterlandEye Doctors of Washington, Chevy Chase, MD, USA.
T GaasterlandScripps Genome Center, University of California at San Diego, San Diego, CA, USA.
D S FriedmanWilmer Eye Institute, Johns Hopkins University Hospital, Baltimore, MD, USA.
C A McCartyEssentia Institute of Rural Health, Duluth, MN, USA.
S E MoroiDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.
L OlsonCenter for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN, USA.
J S SchumanDepartment of Ophthalmology, UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA, USA.
K SinghDepartment of Ophthalmology, Stanford University, Palo Alto, CA, USA.
D VollrathDepartment of Genetics, Stanford University, Palo Alto, CA, USA.
G WollsteinDepartment of Ophthalmology, UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA, USA.
D J ZackWilmer Eye Institute, Johns Hopkins University Hospital, Baltimore, MD, USA.
M BrilliantCenter for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.
A J SitDepartment of Ophthalmology, Mayo Clinic, Rochester, MN, USA.
W G ChristenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
J FingertDepartments of Ophthalmology and Anatomy/Cell Biology, University of Iowa, College of Medicine, Iowa City, IA, USA.
J P FormanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
E S BuysDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
P KraftDepartment of Biostatistics and Epidemiology, Harvard School of Public Health, Boston, MA, USA.
K ZhangDepartment of Ophthalmology and Hamilton Glaucoma Center, University of California at San Diego, San Diego, CA, USA.
R R AllinghamDepartment of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
M A Pericak-VanceBascom Palmer Eye Institute and Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
J E RichardsDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.
M A Hauser1] Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA [2] Department of Medicine, Duke University Medical Center, Durham, NC, USA.
J L HainesCenter for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN, USA.
J L WiggsDepartment of Ophthalmology, Mass Eye and Ear, Boston, MA, USA.
L R Pasquale1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Department of Ophthalmology, Mass Eye and Ear, Boston, MA, USA.ORCID 0000000258353496
Brigham and Women's Hospital · USUniversity of Michigan · USVanderbilt University · USDuke University · USHarvard University · USJohns Hopkins University · USMassachusetts Eye and Ear Infirmary · USStanford University · USUniversity of Miami · USUniversity of Pittsburgh · USDuke Medical Center · USEssentia Health · USMarshfield Clinic · USMayo Clinic in Arizona · USScripps Institution of Oceanography · USUniversity of Iowa · USUniversity of North Carolina at Chapel Hill · USWest Virginia University · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
A Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4M
Novel Glaucoma Diagnostics for Structure and Function - Renewal - 1R01EY013178 · NEI · WILLS EYE HEALTH SYSTEM · PI Joel S Schuman · 2000 to 2026
$17.5M
P30 Core Grant for Vision ResearchP30EY014104 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Eric A Pierce · 2002 to 2026
$15.1M
Dietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6M
Unifying Genetics Epidemiology of Macular DegenerationR01EY012118 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI AGARWAL, ANITA, HAINES, JONATHAN L · 2006 to 2015
$12.2M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
Gene-Environment Interactions in GlaucomaR01EY015473 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI PASQUALE, LOUIS ROBERT · 2005 to 2021
$8.3M
NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1TR000427NCI NIH HHS CA49449NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA87969NCI NIH HHS R01 CA049449NCI NIH HHS U01 CA049449NCI NIH HHS UM1 CA167552NCRR NIH HHS UL1 RR025758NEI NIH HHS 3R01EY015872-05S1NEI NIH HHS 3R01EY019126-02S1NEI NIH HHS EY006827NEI NIH HHS EY008208NEI NIH HHS EY009149NEI NIH HHS EY009847NEI NIH HHS EY010886NEI NIH HHS EY011008NEI NIH HHS EY011671NEI NIH HHS EY012118NEI NIH HHS EY013178NEI NIH HHS EY015473NEI NIH HHS EY015543NEI NIH HHS EY015682NEI NIH HHS EY09580NEI NIH HHS EY09611NEI NIH HHS EY13315NEI NIH HHS EY144428NEI NIH HHS EY144448NEI NIH HHS EY18660NEI NIH HHS P30 EY014104NEI NIH HHS R01 EY008208NEI NIH HHS R01 EY009580NEI NIH HHS R01 EY009611NEI NIH HHS R01 EY009847NEI NIH HHS R01 EY010886NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY011405NEI NIH HHS R01 EY011671NEI NIH HHS R01 EY012118NEI NIH HHS R01 EY013178NEI NIH HHS R01 EY013315NEI NIH HHS R01 EY015473NEI NIH HHS R01 EY015543NEI NIH HHS R01 EY015872NEI NIH HHS R01 EY018660NEI NIH HHS R01 EY019126NEI NIH HHS R01 EY022305NEI NIH HHS R01 EY022306NEI NIH HHS R01 EY022746NEI NIH HHS R01EY022746NEI NIH HHS R01 EY023512NEI NIH HHS R03 EY015682NEI NIH HHS R21 EY022766NEI NIH HHS R56 EY011671NEI NIH HHS U10 EY012118NHGRI NIH HHS HG004424NHGRI NIH HHS HG004446NHGRI NIH HHS HG004608NHGRI NIH HHS HG004728NHGRI NIH HHS HG005259-01NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG004608NHGRI NIH HHS U01 HG004728NHGRI NIH HHS U01 HG006389NHGRI NIH HHS U01HG006389NHLBI NIH HHS HL073389NHLBI NIH HHS HL35464NHLBI NIH HHS R01 HL035464NHLBI NIH HHS R01 HL073389NIDA NIH HHS K02 DA021237
6 · The paper itself

Abstract

aimsVascular perfusion may be impaired in primary open-angle glaucoma (POAG); thus, we evaluated a panel of markers in vascular tone-regulating genes in relation to POAG.

methodsWe used Illumina 660W-Quad array genotype data and pooled P-values from 3108 POAG cases and 3430 controls from the combined National Eye Institute Glaucoma Human Genetics Collaboration consortium and Glaucoma Genes and Environment studies. Using information from previous literature and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, we compiled single-nucleotide polymorphisms (SNPs) in 186 vascular tone-regulating genes. We used the 'Pathway Analysis by Randomization Incorporating Structure' analysis software, which performed 1000 permutations to compare the overall pathway and selected genes with comparable randomly generated pathways and genes in their association with POAG.

resultsThe vascular tone pathway was not associated with POAG overall or POAG subtypes, defined by the type of visual field loss (early paracentral loss (n=224 cases) or only peripheral loss (n=993 cases)) (permuted P≥0.20). In gene-based analyses, eight were associated with POAG overall at permuted P<0.001: PRKAA1, CAV1, ITPR3, EDNRB, GNB2, DNM2, HFE, and MYL9. Notably, six of these eight (the first six listed) code for factors involved in the endothelial nitric oxide synthase activity, and three of these six (CAV1, ITPR3, and EDNRB) were also associated with early paracentral loss at P<0.001, whereas none of the six genes reached P<0.001 for peripheral loss only. DISCUSSION: Although the assembled vascular tone SNP set was not associated with POAG, genes that code for local factors involved in setting vascular tone were associated with POAG.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAgedAMP-Activated Protein KinasesCase-Control StudiesCaveolin 1Dynamin IIDynaminsEndothelium, VascularFemaleGenotypeGlaucoma, Open-AngleGTP-Binding ProteinsHumansInositol 1,4,5-Trisphosphate ReceptorsIntraocular PressureAMP-Activated Protein KinasesCAV1 protein, humanCaveolin 1DNM2 protein, humanDynamin IIDynaminsEDNRB protein, humanGNB2 protein, humanGTP-Binding ProteinsInositol 1,4,5-Trisphosphate ReceptorsITPR3 protein, humanNitric Oxide Synthase Type IIINOS3 protein, humanPRKAA1 protein, humanReceptor, Endothelin BReceptors, Endothelin

Identifiers

PMID24603425
PMCPMC4058608
OpenAlexW2048082333

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.