ArticleThe EMBO journal1988
The structure of cytochrome b561, a secretory vesicle-specific electron transport protein.
Article in The EMBO journal, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 103 citations in OpenAlex.
- Role of the human cytochrome b561 family in iron metabolism and tumors (Review).Oncology letters · 2025Review
- Article
- Novel genetically encoded tools for imaging or silencing neuropeptide release from presynaptic terminalsbioRxiv : the preprint server for biology · 2023Article
- Comparative Analysis of Dorsal Root, Nodose and Sympathetic Ganglia for the Development of New Analgesics.Frontiers in neuroscience · 2020Article
- Molecular organization of Drosophila neuroendocrine cells by Dimmed.Current biology : CB · 2011Article
- Functional and structural roles of residues in the third extramembrane segment of adrenal cytochrome b561.Biochemistry · 2011Article
- His92 and His110 selectively affect different heme centers of adrenal cytochrome b(561).Biochimica et biophysica acta · 2008Article
- Axial ligation and stoichiometry of heme centers in adrenal cytochrome b561.Biochemistry · 2007Article
- Article
- Localization of an ascorbate-reducible cytochrome b561 in the plant tonoplast.Plant physiology · 2004Article
- A phylogenetic study of cytochrome b561 proteins.Genome biology · 2003Article
- b-type cytochromes in plasma membranes of Phaseolus vulgaris hypocotyls, Arabidopsis thaliana leaves, and Zea mays roots.Protoplasma · 2001Article
- Review
- Sorting and storage during secretory granule biogenesis: looking backward and looking forward.The Biochemical journal · 1998Review
- Membrane composition of adrenergic large and small dense cored vesicles and of synaptic vesicles: consequences for their biogenesis.Neurochemical research · 1997Review
- SDS-resistant aggregation of membrane proteins: application to the purification of the vesicular monoamine transporter.The Biochemical journal · 1996Article
- cemA homologue essential to CO2 transport in the cyanobacterium Synechocystis PCC6803.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Detection of gp91-phox precursor protein in B-cell lines from patients with X-linked chronic granulomatous disease as an indicator for mutations impairing cytochrome b558 biosynthesis.The Biochemical journal · 1996Article
- Preferential localization of a vesicular monoamine transporter to dense core vesicles in PC12 cells.The Journal of cell biology · 1994Article
- Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information.The Biochemical journal · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cytochrome b561 is a transmembrane electron transport protein that is specific to a subset of secretory vesicles containing catecholamines and amidated peptides. This protein is thought to supply reducing equivalents to the intravesicular enzymes dopamine-beta-hydroxylase and alpha-peptide amidase. We have purified cytochrome b561 from bovine adrenal chromaffin granules by reverse phase chromatography and have determined internal amino acid sequences from peptides. Complementary oligonucleotides were used to isolate two cDNA clones from a bovine brain library. The structure predicted by the sequences of these cDNAs suggests a highly hydrophobic protein of 273 amino acids which spans the membrane six times with little extramembranous sequence. Cytochrome b561 is not homologous to any other cytochrome and thus represents a new class of electron carriers. RNA blotting experiments indicate that cytochrome b561 is expressed in the adrenal medulla and all brain regions of the cow, but not in visceral organs. This result agrees well with the putative function of this unique cytochrome and with the notion that this protein is localized to large dense-core synaptic vesicles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.