Evidence map›Paper›PMID 2460338›Full record

ArticleThe EMBO journal1988

Differential antero-posterior expression of two proteins encoded by a homeobox gene in Xenopus and mouse embryos.

G Oliver, C V Wright, J Hardwicke, E M De Robertis

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 119 citations in OpenAlex.

  1. Reshuffling genomic landscapes to study the regulatory evolution of Hox gene clusters.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
  2. Article
  3. Article
  4. Review
  5. Hox genes in the lung.American journal of respiratory cell and molecular biology · 1996
    Review
  6. Embryonic expression patterns of the neural cell adhesion molecule gene are regulated by homeodomain binding sites.Proceedings of the National Academy of Sciences of the United States of America · 1996
    Article
  7. Review
  8. Article
  9. Binding and transcriptional activation of the promoter for the neural cell adhesion molecule by HoxC6 (Hox-3.3).Proceedings of the National Academy of Sciences of the United States of America · 1993
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

G OliverDepartment of Biological Chemistry, University of California School of Medicine, Los Angeles 90024.
C V Wright
J Hardwicke
E M De Robertis
University of California, Los Angeles · US

Funding

HOMEOBOX GENES AND THEIR TARGETS IN XENOPUS DEVELOPMENTR37HD021502 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DE ROBERTIS, EDWARD M · 1997 to 2006
$2.2M
HOMEOBOXES IN XENOPUS DEVELOPMENTR01HD021502 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DE ROBERTIS, EDWARD M · 1986 to 2011
$1.6M
NICHD NIH HHS HD 21502-02
6 · The paper itself

Abstract

The X.laevis XlHbox 1 gene uses two functional promoters to produce a short and a long protein, both containing the same homeodomain. In this report we use specific antibodies to localize both proteins in frog embryos. The antibodies also recognize the homologous proteins in mouse embryos. In both mammalian and amphibian embryos, expression of the long protein starts more posteriorly than that of the short protein. This difference in spatial expression applies to the nervous system, the segmented mesoderm and the internal organs. This suggests that each promoter from this gene has precisely restricted regions of expression along the anterior-posterior axis of the embryo. Because the long and short proteins share a common DNA-binding specificity but differ by an 82 amino acid domain, their differential distribution may have distinct developmental consequences.

Indexed as

Genes, HomeoboxAnimalsEpitopesImmunoenzyme TechniquesMesodermMiceNervous SystemProteinsRecombinant Fusion ProteinsSpecies SpecificityXenopus laevisEpitopesProteinsRecombinant Fusion Proteins

Identifiers

PMID2460338
PMCPMC454715
OpenAlexW1564791985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.