ArticleExperimental & molecular medicine2014
Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice.
Article in Experimental & molecular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Robust noninvasive detection of hyperglycemia in mouse models of metabolic dysregulation using the novel Urination Index biomarker.Lab animal · 2025Article
- Diurnal regulation of urinary behavior and gene expression in aged mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Disruption of circadian rhythm as a potential pathogenesis of nocturia.Nature reviews. Urology · 2025Review
- Nocturia and obstructive sleep apnoea.Nature reviews. Urology · 2024Review
- Daily rhythms in metabolic and locomotor behaviour of prematurely ageing PolgA mice.FEBS open bio · 2024Article
- Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice.Communications biology · 2023Article
- Melatonin inhibits muscular-mucosal stretch-sensitive bladder afferents via the MT2 receptors.Scientific reports · 2022Article
- Daily injection of melatonin inhibits insulin resistance induced by chronic mealtime shift.Physiological reports · 2022Article
- Time-of-day dependent changes in guinea pig bladder afferent mechano-sensitivity.Scientific reports · 2021Article
- Microbiota Alters Urinary Bladder Weight and Gene Expression.Microorganisms · 2020Article
- Influence of Circadian Disruption Associated With Artificial Light at Night on Micturition Patterns in Shift Workers.International neurourology journal · 2019Article
- The role of sleep problems and circadian clock genes in attention-deficit hyperactivity disorder and mood disorders during childhood and adolescence: an update.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- Nocturia: The circadian voiding disorder.Investigative and clinical urology · 2016Review
- Do we need to know more about the effects of hormones on lower urinary tract dysfunction? ICI-RS 2014.Neurourology and urodynamics · 2016Review
- A tunable artificial circadian clock in clock-defective mice.Nature communications · 2015Article
- Evaluation of mouse urinary bladder smooth muscle for diurnal differences in contractile properties.Frontiers in pharmacology · 2014Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian clocks are the endogenous oscillators that harmonize a variety of physiological processes within the body. Although many urinary functions exhibit clear daily or circadian variation in diurnal humans and nocturnal rodents, the precise mechanisms of these variations are as yet unclear. In the present study, we demonstrate that Per2 promoter activity clearly oscillates in neonate and adult bladders cultured ex vivo from Per2::Luc knock-in mice. In subsequent experiments, we show that multiple local oscillators are operating in all the bladder tissues (detrusor, sphincter and urothelim) and the lumbar spinal cord (L4-5) but not in the pontine micturition center or the ventrolateral periaqueductal gray of the brain. Accordingly, the water intake and urine volume exhibited daily and circadian variations in young adult wild-type mice but not in Per1(-/-)Per2(-/-) mice, suggesting a functional clock-dependent nature of the micturition rhythm. Particularly in PDK mice, the water intake and urinary excretion displayed an arrhythmic pattern under constant darkness, and the amount of water consumed and excreted significantly increased compared with those of WT mice. These results suggest that local circadian clocks reside in three types of bladder tissue and the lumbar spinal cord and may have important roles in the circadian control of micturition function.
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