ArticleScientific reports2014
Pupillometry reveals a mechanism for the Autism Spectrum Disorder (ASD) advantage in visual tasks.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed.
- Atypical Attentional Effort During Visual Search in Autistic Adults: Evidence From Task-Evoked Pupillary Responses.Autism research : official journal of the International Society for Autism Research · 2026Article
- Visual Search Performance in Children With ASD: A Combined Case-Control and Longitudinal Study.Autism research : official journal of the International Society for Autism Research · 2026Article
- Towards Mechanism-Informed Treatments for Mental Health.Journal of neurochemistry · 2026Review
- The Influence of Hearing Aid Type on Reading: Results of an Eye-Tracking Study at University.Audiology research · 2026Article
- Altered brain state dynamics between preterm and term-born infants.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- First steps into the pupillometry multiverse of developmental science.Behavior research methods · 2024Article
- Preverbal infants' understanding of social norms.Scientific reports · 2024Article
- Interest paradigm for early identification of autism spectrum disorder: an analysis from electroencephalography combined with eye tracking.Frontiers in neuroscience · 2024Article
- Elevated and accelerated: Locus coeruleus activity and visual search abilities in autistic children.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Reduced Pupil Oscillation During Facial Emotion Judgment in People with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2023Article
- The Central Noradrenergic System in Neurodevelopmental Disorders: Merging Experimental and Clinical Evidence.International journal of molecular sciences · 2023Review
- Sensory salience processing moderates attenuated gazes on faces in autism spectrum disorder: a case-control study.Molecular autism · 2023Article
- From pupil to the brain: New insights for studying cortical plasticity through pupillometry.Frontiers in neural circuits · 2023Review
- Pupil-Linked Arousal Response Reveals Aberrant Attention Regulation among Children with Autism Spectrum Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Slower Peak Pupillary Response to Emotional Faces in Parents of Autistic Individuals.Frontiers in psychology · 2022Article
- Associations between the pupil light reflex and the broader autism phenotype in children and adults.Frontiers in human neuroscience · 2022Article
- Eye pupil - a window into central autonomic regulation via emotional/cognitive processing.Physiological research · 2021Review
- Updating Expectations About Unexpected Object Motion in Infants Later Diagnosed with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2021Article
- Pupillary Responses Obey Emmert's Law and Co-vary with Autistic Traits.Journal of autism and developmental disorders · 2021Article
- Resting and Functional Pupil Response Metrics Indicate Features of Reward Sensitivity and ASD in Children.Journal of autism and developmental disorders · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Research on the neural underpinnings of Autism Spectrum Disorder (ASD) has focussed primarily on impairments of social interaction and communication. Less is known though about the second diagnostic criterion of restricted behaviors and interests. Uniquely in this domain, alongside impairments stands an 'ASD advantage' characterised by superior performance on many visual tasks. We recently found that 2-year-olds with ASD dramatically outperform age-matched, typically developing controls on visual search. Here we use task-evoked, phasic pupil responses--a sensitive, involuntary measure of effort and a biomarker of the locus coeruleus-norepinephrine (LC-NE) system's modulation of attention--to isolate a causal factor: a 'hyperphasic' LC-NE system compels (here, advantageously) focussed attention. However, this focussed attention in other contexts may contribute to restricted behaviors and interests.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.