ArticleScientific reports2014
A selective glutathione probe based on AIE fluorogen and its application in enzymatic activity assay.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 84 citations in OpenAlex.
- Alkynylated and triazole-linked aroyl-S,N-ketene acetals: one-pot synthesis of solid-state emissive dyes with aggregation-induced enhanced emission characteristics.Scientific reports · 2023Article
- Fluorescent Sensing of Glutathione and Related Bio-Applications.Biosensors · 2022Review
- Synthesis of Metal-Organic Frameworks Quantum Dots Composites as Sensors for Endocrine-Disrupting Chemicals.International journal of molecular sciences · 2022Review
- Chemically Responsive Photonic Crystal Hydrogels for Selective and Visual Sensing of Thiol-Containing Biomolecules.ACS omega · 2019Article
- MRI/Fluorescence bimodal amplification system for cellular GSH detection and tumor cell imaging based on manganese dioxide nanosheet.Scientific reports · 2018Article
- Naphthalene-based fluorescent probes for glutathione and their applications in living cells and patients with sepsis.Theranostics · 2018Article
- Novel approaches in function-driven single-cell genomics.FEMS microbiology reviews · 2017Article
- Real time monitoring of aminothiol level in blood using a near-infrared dye assisted deep tissue fluorescence and photoacoustic bimodal imaging.Chemical science · 2016Article
- Single near-infrared fluorescent probe with high- and low-sensitivity sites for sensing different concentration ranges of biological thiols with distinct modes of fluorescence signals.Chemical science · 2016Article
- A highly specific probe for sensing hydrogen sulfide in live cells based on copper-initiated fluorogen with aggregation-induced emission characteristics.Theranostics · 2014Article
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, we design and synthesize a malonitrile-functionalized TPE derivative (TPE-DCV), which can react with thiol group through thiol-ene click reaction, leading to the fluorescence change of the system. Combined with the unique AIE property, TPE-DCV can selectively detect glutathione (GSH) but not cysteine or homocysteine. As the cleavage of GSSG with the aid of glutathione reductase produces GSH, which turns on the fluorescence of TPE-DCV, the ensemble of TPE-DCV and GSSG can thus serve as a label-free sensor for enzymatic activity assay of glutathione reductase. We also apply TPE-DCV for the detection of intracellular GSH in living cells.
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