ArticleVirulence2014
The maternal transfer of bacteria can mediate trans-generational immune priming in insects.
Article in Virulence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed, 178 citations in OpenAlex.
- Loss of vitellogenin receptor function results in yolk depletion, virome expansion, and reduced bacterial load within the oocytes of Rhodnius prolixus.BMC biology · 2026Article
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- Master of Puppets: How Microbiota Drive the Nematoda Ecology and Evolution?Ecology and evolution · 2025Review
- Microbial Symbiosis in Lepidoptera: Analyzing the Gut Microbiota for Sustainable Pest Management.Biology · 2025Review
- Current insights into insect immune memory.eLife · 2025Review
- Significant variations of bacterial communities among the developmental stages of Scirpophaga incertulas (Walker) (Lepidoptera: Crambidae).Scientific reports · 2025Article
- Immune challenges and pathogen risks in edible insects: safeguarding health in space life-support systems.Frontiers in physiology · 2025Review
- Evidence for trans-generational immune priming againstFrontiers in immunology · 2025Article
- Microbiome analysis of monarch butterflies reveals effects of development and diet.FEMS microbiology ecology · 2024Article
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- The Effects of Egg- and Substrate-Associated Microbiota on the Larval Performance of the Housefly,Insects · 2024Article
- Unveiling the Microbiome Diversity inInsects · 2024Article
- Haemolymph transfusions transfer heritable learned novel odour preferences to naive larvae ofBiology letters · 2024Article
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- Immune priming modulatesFrontiers in immunology · 2024Article
- Dynamic Gut Microbiota of Apolygus lucorum Across Different Life Stages Reveals Potential Pathogenic Bacteria for Facilitating the Pest Management.Microbial ecology · 2023Article
- Article
- Lepidopteran insects: emerging model organisms to study infection by enteropathogens.Folia microbiologica · 2023Review
- Galleria mellonella-intracellular bacteria pathogen infection models: the ins and outs.FEMS microbiology reviews · 2023Review
- Spiramycin DisarmsAntibiotics (Basel, Switzerland) · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parents invest in their offspring by preparing them for defense against pathogens and parasites that only the parents have encountered, a phenomenon known as trans-generational immune priming. We investigated the underlying mechanism using the established lepidopteran model host Galleria mellonella. When larvae were fed with non-pathogenic bacteria, or the entomopathogenic species Pseudomonas entomophila and Serratia entomophila, the activity of lysozyme and phenoloxidase increased in the hemolymph, and immunity-related genes encoding antibacterial proteins such as gloverin were induced. Remarkably, the ingestion of bacteria by female larvae resulted in the differential expression of immunity-related genes in the eggs subsequently laid by the same females, providing evidence for trans-generational immune priming in G. mellonella. To determine the fate of these ingested microbes, the larval diet was supplemented with bacteria carrying a fluorescent label. We observed these bacteria crossing the midgut epithelium, their entrapment within nodules in the hemocoel, their accumulation within the ovary, and ultimately their deposition in the eggs. Therefore, we propose that trans-generational immune priming in Lepidoptera can be mediated by the maternal transfer of bacteria or bacterial fragments to the developing eggs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.