ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2014
Efficacy of various analgesics on shoulder function and rotator cuff tendon-to-bone healing in a rat (Rattus norvegicus) model.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Trial
- Acetaminophen Inhibits Fatty Infiltration without Impairing Tendon-Bone Interface Healing in a Rat Model of Acute Rotator Cuff Repair.Clinics in orthopedic surgery · 2025Article
- Temporal disruption of neuromuscular communication and muscle atrophy following noninvasive ACL injury in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Relationship between altered knee kinematics and subchondral bone remodeling in a clinically translational model of ACL injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Evaluation of animal models and methods for assessing shoulder function after rotator cuff tear: A systematic review.Journal of orthopaedic translation · 2021Review
- Effects of Pulsed Electromagnetic Field Therapy on Rat Achilles Tendon Healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Influence of Pain and Analgesia on Orthopedic and Wound-healing Models in Rats and Mice.Comparative medicine · 2019Review
- A novel device to measure static hindlimb weight-bearing forces in pronograde rodents.Journal of neuroscience methods · 2019Article
- Clinical Management of Pain in Rodents.Comparative medicine · 2019Review
- Ultrasound Evaluation of Anti-Vascular Endothelial Growth Factor-Induced Changes in Vascular Response Following Tendon Injury.Ultrasound in medicine & biology · 2019Article
- Quantitative comparison of three rat models of Achilles tendon injury: A multidisciplinary approach.Journal of biomechanics · 2019Article
- Pulsed electromagnetic field therapy improves tendon-to-bone healing in a rat rotator cuff repair model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- The effects of pentoxifylline adminstration on fracture healing in a postmenopausal osteoporotic rat model.Laboratory animal research · 2017Article
- Effect of simvastatin on rat supraspinatus tendon mechanical and histological properties in a diet-induced hypercholesterolemia model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Ground reaction forces are more sensitive gait measures than temporal parameters in rodents following rotator cuff injury.Journal of biomechanics · 2016Article
- Pain and Laboratory Animals: Publication Practices for Better Data Reproducibility and Better Animal Welfare.PloS one · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although relief of postoperative pain is an imperative aspect of animal welfare, analgesics that do not interfere with the scientific goals of the study must be used. Here we compared the efficacy of different analgesic agents by using an established rat model of supraspinatus tendon healing and a novel gait-analysis system. We hypothesized that different analgesic agents would all provide pain relief in this model but would cause differences in tendon-to-bone healing and gait parameters. Buprenorphine, ibuprofen, tramadol-gabapentin, and acetaminophen were compared with a no-analgesia control group. Gait measures (stride length and vertical force) on the operative forelimb differed between the control group and both the buprenorphine (2 and 4 d postsurgery) and ibuprofen (2 d postsurgery) groups. Step length was different in the control group as compared with the tramadol-gabapentin (2 d after surgery), buprenorphine (2 and 4 d after surgery), and ibuprofen (2 d after surgery) groups. Regarding tendon-to-bone healing, the ibuprofen group showed less stiffness at the insertion site; no other differences in tendon-to-bone healing were detected. In summary, the analgesics evaluated were associated with differences in both animal gait and tendon-to-bone healing. This information will be useful for improving the management of postsurgical pain without adversely affecting tissue healing. Given its ability to improve gait without impeding healing, we recommend use of buprenorphine for postsurgical pain management in rats. In addition, our gait-analysis system can be used to evaluate new analgesics.
Indexed as
Identifiers
24602546PMC3966276W2288714749What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.