SynthesisBMC neurology2014
Cerebrovascular function and cognition in childhood: a systematic review of transcranial Doppler studies.
Synthesis in BMC neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Correlates of Cognitive Function in Sickle Cell Disease: A Meta-Analysis.Journal of pediatric psychology · 2020Pooled it
- The Effects of Taekwondo Training on Peripheral Neuroplasticity-Related Growth Factors, Cerebral Blood Flow Velocity, and Cognitive Functions in Healthy Children: A Randomized Controlled Trial.International journal of environmental research and public health · 2017Trial
- Predictive value of transcranial Doppler ultrasound for brain development and craniocerebral injury in premature infants.American journal of translational research · 2025Article
- Brain Volumes and Cognition in Patients with Sickle Cell Anaemia: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- Neuroimaging and Cognitive Function in Sickle Cell Disease: A Systematic Review.Children (Basel, Switzerland) · 2023Review
- Evaluation of Cerebral Vasomotor Reactivity by Transcranial Doppler Ultrasound in Patients with Diabetic Retinopathy.Neuro-ophthalmology (Aeolus Press) · 2023Article
- Neurocognitive Changes in Sickle Cell Disease: A Comprehensive Review.Annals of neurosciences · 2022Review
- Article
- Pediatric Traumatic Brain Injury: An Update on Preclinical Models, Clinical Biomarkers, and the Implications of Cerebrovascular Dysfunction.Journal of central nervous system disease · 2022Review
- ApoE and cerebral insulin: Trafficking, receptors, and resistance.Neurobiology of disease · 2020Review
- Laboratory Biomarkers, Cerebral Blood Flow Velocity, and Intellectual Function in Children with Sickle Cell Disease.Advances in hematology · 2020Article
- Associations of transcranial doppler velocity, age, and gender with cognitive function in children with sickle cell anemia in Nigeria.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2019Article
- Neurological Injury and Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction.Circulation · 2017Article
- Higher subcortical and white matter cerebral blood flow in perinatally HIV-infected children.Medicine · 2017Observational
- Measuring cerebral hemodynamic changes during action observation with functional transcranial doppler.Journal of physical therapy science · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe contribution of cerebrovascular function to cognitive performance is gaining increased attention. Transcranial doppler (TCD) is portable, reliable, inexpensive and extremely well tolerated by young and clinical samples. It enables measurement of blood flow velocity in major cerebral arteries at rest and during cognitive tasks.
methodsWe systematically reviewed evidence for associations between cognitive performance and cerebrovascular function in children (0-18 years), as measured using TCD. A total of 2778 articles were retrieved from PsychInfo, Pubmed, and EMBASE searches and 25 relevant articles were identified.
resultsMost studies investigated clinical groups, where decreased blood flow velocities in infants were associated with poor neurological functioning, and increased blood flow velocities in children with Sickle cell disease were typically associated with cognitive impairment and lower intelligence. Studies were also identified assessing autistic behaviour, mental retardation and sleep disordered breathing. In healthy children, the majority of studies reported cognitive processing produced lateralised changes in blood flow velocities however these physiological responses did not appear to correlate with behavioural cognitive performance.
conclusionPoor cognitive performance appears to be associated with decreased blood flow velocities in premature infants, and increased velocities in Sickle cell disease children using TCD methods. However knowledge in healthy samples is relatively limited. The technique is well tolerated by children, is portable and inexpensive. It therefore stands to make a valuable contribution to knowledge regarding the underlying functional biology of cognitive performance in childhood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.