Evidence map›Paper›PMID 24602337›Full record

ArticleBMC musculoskeletal disorders2014

Twins discordant for myositis and systemic lupus erythematosus show markedly enriched autoantibodies in the affected twin supporting environmental influences in pathogenesis.

Lu Gan, Terrance P O'Hanlon, Aaron S Gordon, Lisa G Rider, Frederick W Miller, Peter D Burbelo

Registry-linked trialOpen access · goldAbstract readComparative StudyTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00055055 (Pathogenic Studies In Families With Twins Or Siblings Discordant For Systemic Rheumatic Disorders), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00055055 completednot on this map

Pathogenic Studies In Families With Twins Or Siblings Discordant For Systemic Rheumatic Disorders

TypeobservationalSponsorNational Institute of Environmental Health Sciences (NIEHS)Ran2003Enrolled1,056ConditionsRheumatoid Arthritis, Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. [Advances in epigenetic markers of dermatomyositis/polymyositis].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019
    Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lu Gan
Terrance P O'Hanlon
Aaron S Gordon
Lisa G Rider
Frederick W MillerEnvironmental Autoimmunity Group, National Institute of Environmental Health Sciences, Bethesda, MD, USA. millerf@mail.nih.gov.
Peter D Burbelo
National Institutes of Health · USNational Institute of Dental and Craniofacial Research · US

Funding

Environmental/genetic Risk Factors and Pathogenesis of Autoimmune DiseaseZIAES101074 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RIDER, LISA · 2009 to 2025
$34.6M
Intramural NIH HHS
6 · The paper itself

Abstract

backgroundStudies of twin pairs discordant for autoimmune conditions provide a unique opportunity to explore contributing factors triggered by complex gene-environment interactions.

methodsIn this cross-sectional study, thirty-one monozygotic or dizygotic twin pairs discordant for myositis or systemic lupus erythematosus (SLE), along with matched healthy controls were evaluated for antibodies against a panel of 21 autoantigens.

resultsAutoantibody profiling revealed that 42% of the affected twins showed significant seropositivity against autoantigens in the panel. In many of these affected twins, but none of healthy controls, there were high levels of autoantibodies detected against two or more autoantigens commonly seen in systemic autoimmune diseases including Ro52, Ro60, RNP-70 K and/or RNP-A. In contrast, only 10% (3/31) of the unaffected twins showed seropositivity and these immunoreactivities were against single autoantigens not seen in systemic autoimmune diseases. While no significant differences in autoantibodies were detected between the affected or unaffected twins against thyroid peroxidase, transglutaminase and several cytokines, 23% of the affected twins with myositis showed autoantibodies against the gastric ATPase. Analysis of the monozygotic twins separately also revealed a higher frequencies of autoantibodies in the affected twins compared to the unaffected twins (P = 0.046). Lastly, clinical analysis of both the affected monozygotic and dizygotic twins revealed that the autoantibody seropositive affected twins had a greater global disease activity score compared to seronegative affected twins (P = 0.019).

conclusionThe findings of significantly more autoantibodies in the affected twins with myositis and SLE compared to the unaffected twins are consistent with potential non-genetic factors playing a role in autoantibody production and pathogenesis of these autoimmune disorders.

Indexed as

Gene-Environment InteractionAdolescentAutoantibodiesAutoantigensCase-Control StudiesChildCross-Sectional StudiesCytokinesFemaleGTP-Binding ProteinsHumansImmunoprecipitationInterferon-gammaIodide PeroxidaseIron-Binding ProteinsLuciferasesAutoantibodiesAutoantigensCytokinesGTP-Binding ProteinsInterferon-gammaIodide PeroxidaseIron-Binding ProteinsLuciferasesNuclear ProteinsProtein Glutamine gamma Glutamyltransferase 2thyroid microsomal antibodiesTPO protein, humanTransglutaminases

Identifiers

PMID24602337
PMCPMC3973849
OpenAlexW2070133355

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.