ArticleBJOG : an international journal of obstetrics and gynaecology2014
Predictors of adverse pregnancy outcomes in women infected with HIV in Latin America and the Caribbean: a cohort study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adverse perinatal outcomes associated with prenatal exposure to protease-inhibitor-based versus non-nucleoside reverse transcriptase inhibitor-based antiretroviral combinations in pregnant women with HIV infection: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2023Pooled it
- Raltegravir versus efavirenz in antiretroviral-naive pregnant women living with HIV (NICHD P1081): an open-label, randomised, controlled, phase 4 trial.The lancet. HIV · 2020Trial
- Article
- RNA Viruses, Pregnancy and Vaccination: Emerging Lessons from COVID-19 and Ebola Virus Disease.Pathogens (Basel, Switzerland) · 2022Review
- Effects of HIV Infection on Pregnancy Outcomes Among Women Attending Antenatal Care in Referral Hospitals of the Amhara Regional State, Ethiopia: A Prospective Cohort Study.International journal of women's health · 2022Article
- Viral Infections During Pregnancy: The Big Challenge Threatening Maternal and Fetal Health.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022Article
- A cross-sectional evaluation of HIV testing practices among women in the rural Dominican Republic.BMC women's health · 2020Article
- Maternal HIV infection and risk of adverse pregnancy outcomes in Hunan province, China: A prospective cohort study.Medicine · 2020Observational
- A Multicenter Analysis of Elvitegravir Use During Pregnancy on HIV Viral Suppression and Perinatal Outcomes.Open forum infectious diseases · 2019Article
- Syphilis and human immunodeficiency virus infections among pregnant women attending antenatal care clinic of Gondar family guidance association, Northwest Ethiopia: implication for prevention of mother to child transmission.Reproductive health · 2019Article
- Outcomes Following Pregnancy Conception on Antiretroviral Therapy: A Call for More Data.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Adverse effects in children exposed to maternal HIV and antiretroviral therapy during pregnancy in Brazil: a cohort study.Reproductive health · 2018Article
- Preconception use of cART by HIV-positive pregnant women increases the risk of infants being born small for gestational age.PloS one · 2018Observational
- Smoking, HIV, and risk of pregnancy loss.AIDS (London, England) · 2017Observational
- Article
- Pregnancy outcomes following exposure to efavirenz based antiretroviral therapy in indian women.Indian journal of pharmacologyObservational
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9 authors.
Funding
Abstract
objectiveTo examine maternal characteristics associated with adverse pregnancy outcomes among women infected with HIV.
designProspective cohort study.
settingMultiple sites in Latin America and the Caribbean. POPULATION: Women infected with HIV enrolled in the Perinatal (2002-2007) and the Longitudinal Study in Latin American Countries (LILAC; 2008-2012) studies of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) International Site Development Initiative (NISDI).
methodsFrequencies of adverse pregnancy outcomes assessed among pregnancies. Risk factors investigated by logistic regression analysis.
main outcome measuresAdverse pregnancy outcomes, including preterm delivery (PT), low birthweight (LBW), small for gestational age (SGA), stillbirth (SB), and neonatal death.
resultsAmong 1512 women, 1.9% (95% confidence interval, 95% CI, 1.3-2.7) of singleton pregnancies resulted in a stillbirth and 32.9% (95% CI 30.6-35.4) had at least one adverse pregnancy outcome. Of 1483 singleton live births, 19.8% (95% CI 17.8-21.9) were PT, 14.2% (95% CI 12.5-16.1) were LBW, 12.6% (95% CI 10.9-14.4) were SGA, and 0.4% (95% CI 0.2-0.9) of infants died within 28 days of birth. Multivariable logistic regression modelling indicated that the following risk factors increased the probability of having one or more adverse pregnancy outcomes: lower maternal body mass index at delivery (odds ratio, OR, 2.2; 95% CI 1.4-3.5), hospitalisation during pregnancy (OR 3.3; 95% CI 2.0-5.3), hypertension during pregnancy (OR 2.7; 95% CI 1.5-4.8), antiretroviral use at conception (OR 1.4; 95% CI 1.0-1.9), and tobacco use during pregnancy (OR 1.7; 95% CI 1.3-2.2). The results of fitting multivariable logistic regression models for PT, LBW, SGA, and SB are also reported.
conclusionsWomen infected with HIV had a relatively high occurrence of adverse pregnancy outcomes, and some maternal risk factors were associated with these adverse pregnancy outcomes. Interventions targeting modifiable risk factors should be evaluated further.
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