ArticleMolecular microbiology2014
A 5' UTR-mediated translational efficiency mechanism inhibits the Candida albicans morphological transition.
Article in Molecular microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- Ume6 protein complexes connect morphogenesis, adherence and hypoxic genes to shape Candida albicans biofilm architecture.Nature microbiology · 2025Article
- Roles of P-body factors inbioRxiv : the preprint server for biology · 2025Article
- Ribosome profiling reveals differences in global translational vs transcriptional gene expression changes during earlyMicrobiology spectrum · 2025Article
- Roles of P-body factors in Candida albicans filamentation and stress response.PLoS genetics · 2025Article
- A Brg1-Rme1 circuit inmBio · 2024Article
- Genome-wide translational response ofMicrobiology spectrum · 2023Article
- Imaging-Based Screening Identifies Modulators of theAntimicrobial agents and chemotherapy · 2023Article
- Imaging-based screening identifies modulators of thebioRxiv : the preprint server for biology · 2023Article
- Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity.Cell reports · 2022Article
- Intraspecies Transcriptional Profiling Reveals Key Regulators of Candida albicans Pathogenic Traits.mBio · 2021Article
- Global translational landscape of the Candida albicans morphological transition.G3 (Bethesda, Md.) · 2021Article
- The Roles of Chromatin Accessibility in Regulating theJournal of fungi (Basel, Switzerland) · 2021Review
- Regulatory mechanisms controlling morphology and pathogenesis in Candida albicans.Current opinion in microbiology · 2019Review
- Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection.Cell host & microbe · 2019Article
- The 5' Untranslated Region of themSphere · 2018Article
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- The Candida albicans HIR histone chaperone regulates the yeast-to-hyphae transition by controlling the sensitivity to morphogenesis signals.Scientific reports · 2017Article
- Bypass of Candida albicans Filamentation/Biofilm Regulators through Diminished Expression of Protein Kinase Cak1.PLoS genetics · 2016Article
- Control of Candida albicans morphology and pathogenicity by post-transcriptional mechanisms.Cellular and molecular life sciences : CMLS · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
While virulence properties of Candida albicans, the most commonly isolated human fungal pathogen, are controlled by transcriptional and post-translational mechanisms, considerably little is known about the role of post-transcriptional, and particularly translational, mechanisms. We demonstrate that UME6, a key filament-specific transcriptional regulator whose expression level is sufficient to determine C. albicans morphology and promote virulence, has one of the longest 5' untranslated regions (UTRs) identified in fungi to date, which is predicted to form a complex and extremely stable secondary structure. The 5' UTR inhibits the ability of UME6, when expressed at constitutive high levels, to drive complete hyphal growth, but does not cause a reduction in UME6 transcript. Deletion of the 5' UTR increases C. albicans filamentation under a variety of conditions but does not affect UME6 transcript level or induction kinetics. We show that the 5' UTR functions to inhibit Ume6 protein expression under several filament-inducing conditions and specifically reduces association of the UME6 transcript with polysomes. Overall, our findings suggest that translational efficiency mechanisms, known to regulate diverse biological processes in bacterial and viral pathogens as well as higher eukaryotes, have evolved to inhibit and fine-tune morphogenesis, a key virulence trait of many human fungal pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.