ArticleJournal of the American Chemical Society2014
Tuning the biological activity profile of antibacterial polymers via subunit substitution pattern.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- PK/PD Modeling of a Novel Pleuromutilin Derivative Pleuro2-4 against Mycoplasma gallisepticum in Chicks.Journal of agricultural and food chemistry · 2026Article
- AI-guided few-shot inverse design of HDP-mimicking polymers against drug-resistant bacteria.Nature communications · 2024Article
- Facial amphiphilicity index correlating chemical structures with antimicrobial efficacy.Bioactive materials · 2023Article
- Switching from membrane disrupting to membrane crossing, an effective strategy in designing antibacterial polypeptide.Science advances · 2023Article
- Glycopolymers for Antibacterial and Antiviral Applications.Molecules (Basel, Switzerland) · 2023Review
- Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups.Journal of enzyme inhibition and medicinal chemistry · 2022Article
- Main-chain flexibility and hydrophobicity of ionenes strongly impact their antimicrobial activity: an extended study on drug resistance strains andRSC advances · 2022Article
- Article
- Artificial neural network for cytocompatibility and antibacterial enhancement induced by femtosecond laser micro/nano structures.Journal of nanobiotechnology · 2022Article
- Ni Nanocrystals Supported on Graphene Oxide: Antibacterial Agents for Synergistic Treatment of Bacterial Infections.ACS omega · 2022Article
- Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies.Chemical science · 2022Review
- Local rigidification and possible coacervation of the Escherichia coli DNA by cationic nylon-3 polymers.Biophysical journal · 2021Article
- Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers.Bioactive materials · 2021Article
- Host Defense Peptide-Mimicking Polymers and Polymeric-Brush-Tethered Host Defense Peptides: Recent Developments, Limitations, and Potential Success.Pharmaceutics · 2021Review
- Addressing MRSA infection and antibacterial resistance with peptoid polymers.Nature communications · 2021Article
- Cationic Homopolymers Inhibit Spore and Vegetative Cell Growth ofACS infectious diseases · 2021Article
- Beyond Amphiphilic Balance: Changing Subunit Stereochemistry Alters the Pore-Forming Activity of Nylon-3 Polymers.Journal of the American Chemical Society · 2021Article
- Diverse Impacts on Prokaryotic and Eukaryotic Membrane Activities from Hydrophobic Subunit Variation Among Nylon-3 Copolymers.ACS chemical biology · 2021Article
- Branched amphotericin functional poly(Royal Society open science · 2021Article
- Amphiphilic Cationic Macromolecules Highly Effective Against Multi-Drug Resistant Gram-Positive Bacteria and Fungi With No Detectable Resistance.Frontiers in bioengineering and biotechnology · 2020Article
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10 authors.
Funding
Abstract
Binary nylon-3 copolymers containing cationic and hydrophobic subunits can mimic the biological properties of host-defense peptides, but relationships between composition and activity are not yet well understood for these materials. Hydrophobic subunits in previously studied examples have been limited mostly to cycloalkane-derived structures, with cyclohexyl proving to be particularly promising. The present study evaluates alternative hydrophobic subunits that are isomeric or nearly isomeric with the cyclohexyl example; each has four sp(3) carbons in the side chains. The results show that varying the substitution pattern of the hydrophobic subunit leads to relatively small changes in antibacterial activity but causes significant changes in hemolytic activity. We hypothesize that these differences in biological activity profile arise, at least in part, from variations among the conformational propensities of the hydrophobic subunits. The α,α,β,β-tetramethyl unit is optimal among the subunits we have examined, providing copolymers with potent antibacterial activity and excellent prokaryote vs eukaryote selectivity. Bacteria do not readily develop resistance to the new antibacterial nylon-3 copolymers. These findings suggest that variation in subunit conformational properties could be generally valuable in the development of synthetic polymers for biological applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.