Evidence map›Paper›PMID 24601592›Full record

ArticleJournal of medicinal chemistry2014

Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis.

Lorcan Browne, Katie Lidster, Sarah Al-Izki, Lisa Clutterbuck, Cristina Posada, A W Edith Chan, Dieter Riddall, John Garthwaite, David Baker, David L Selwood

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lorcan BrowneBiological and Medicinal Chemistry, Wolfson Institute for Biomedical Science, University College London , Gower Street, London WC1E 6BT, United Kingdom.
Katie Lidster
Sarah Al-Izki
Lisa Clutterbuck
Cristina Posada
A W Edith Chan
Dieter Riddall
John Garthwaite
David Baker
David L Selwood
University College London · GBQueen Mary University of London · GB

Funding

Medical Research Council 84702Medical Research Council G0700729Medical Research Council MC_PC_13037National Centre for the Replacement, Refinement and Reduction of Animals in Research G1000094/1Wellcome Trust 081512
6 · The paper itself

Abstract

A series of imidazol-1-ylethylindazole sodium channel ligands were developed and optimized for sodium channel inhibition and in vitro neuroprotective activity. The molecules exhibited displacement of a radiolabeled sodium channel ligand and selectivity for blockade of the inactivated state of cloned neuronal Nav channels. Metabolically stable analogue 6 was able to protect retinal ganglion cells during optic neuritis in a mouse model of multiple sclerosis.

Indexed as

Disease Models, AnimalAnimalsFemaleHumansImidazolesLymph NodesMaleMiceMice, Inbred C57BLMice, TransgenicMultiple SclerosisNeuroprotective AgentsOptic NeuritisRetinal Ganglion CellsVoltage-Gated Sodium ChannelsImidazolesNeuroprotective AgentsVoltage-Gated Sodium Channels

Identifiers

PMID24601592
PMCPMC4010550
OpenAlexW2168650726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.