Evidence map›Paper›PMID 24600532›Full record

ArticleGeriatric orthopaedic surgery & rehabilitation2013

Outcomes of total knee arthroplasty in relation to preoperative patient-reported and radiographic measures: data from the osteoarthritis initiative.

Timothy L Kahn, Aydin Soheili, Ran Schwarzkopf

Registry-linked trialAbstract read
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In one paragraph

Article in Geriatric orthopaedic surgery & rehabilitation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06608134 (Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for), which is not on this map. Cited by 40 papers, 4 of them syntheses that pooled it.

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0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06608134 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for

TypeinterventionalSponsorR3 Medical ResearchRan2024 to 2029Enrolled120ConditionsOsteoarthritis, KneeArmsUmbilical Cord Wharton's Jelly Allograft Intra-articular Knee Injection
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  13. Preoperative Patient-Reported Outcomes Predict Candidacy for Outpatient Total Knee Arthroplasty.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025
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  18. Severity Of Radiographic Osteoarthritis: Association with Improved Patient Reported Outcomes Following Knee Arthroplasty.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Timothy L KahnDepartment of Orthopaedics, Joint replacement Service, University of California, Irvine Medical Center, Irvine, CA, USA.
Aydin SoheiliDepartment of Orthopaedics, Joint replacement Service, University of California, Irvine Medical Center, Irvine, CA, USA.
Ran SchwarzkopfDepartment of Orthopaedics, Joint replacement Service, University of California, Irvine Medical Center, Irvine, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTotal knee arthroplasty (TKA) is the preferred surgical treatment for end-stage osteoarthritis. However, substantial numbers of patients still experience poor outcomes. Consequently, it is important to identify which patient characteristics are predictive of outcomes in order to guide clinical decisions. Our hypothesis is that preoperative patient-reported outcome measures and radiographic measures may help to predict TKA outcomes.

methodsUsing cohort data from the Osteoarthritis Initiative, we studied 172 patients who underwent TKA. For each patient, we compiled pre- and postoperative Western Ontario and McMaster University Arthritis Index (WOMAC) scores. Radiographs were measured for knee joint angles, femorotibial angles, anatomical lateral distal femoral angles, and anatomical medial proximal tibial angles; Kellgren and Lawrence (KL) grades were assigned to each compartment of the knee. All studied measurements were compared to WOMAC outcomes.

resultsPreoperative WOMAC disability, pain, and total scores were positively associated with postoperative WOMAC total scores (P = .010, P = .010, and P = .009, respectively) and were associated with improvement in WOMAC total scores (P < .001, P < .001, and P < .001, respectively). For radiographic measurements, preoperative joint angles were positively associated with improvements in postoperative WOMAC total scores (P = .044). Combined KL grades (medial and lateral compartments) were negatively correlated with postoperative WOMAC disability and pain scores (P = .045 and P = .044) and were positively correlated with improvements in WOMAC total scores (P = .001).

conclusionsAll preoperative WOMAC scores demonstrated positive associations with postoperative WOMAC scores, while among the preoperative radiographic measurements only combined KL grades and joint angles showed any correlation with postoperative WOMAC scores. Higher preoperative KL grades and joint angles were associated with better (lower) postoperative WOMAC scores, demonstrating an inverse correlation.

Indexed as

Kellgren and Lawrence gradesoutcome predictorspatient-reported outcome measuresprimary total knee arthroplastyradiographic measures

Identifiers

PMID24600532
PMCPMC3943364

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