ArticleInternational journal of clinical and experimental medicine2014
Correlations between MMP-2/MMP-9 promoter polymorphisms and ischemic stroke.
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- The Role of Biomarkers in Atherothrombotic Stroke-A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Meta-analysis of matrix metalloproteinase (MMP)-9 C1562T polymorphism and susceptibility to ischemic stroke in the Chinese population.The Journal of international medical research · 2020Pooled it
- Article
- Matrix Metalloproteinases in Cardioembolic Stroke: From Background to Complications.International journal of molecular sciences · 2023Review
- Does the functional polymorphism-1562C/T of MMP-9 gene influence brain disorders?Frontiers in cellular neuroscience · 2023Review
- The roles of MMP8/MMP10 polymorphisms in ischemic stroke susceptibility.Brain and behavior · 2022Article
- MMP9 SNP and MMP SNP-SNP interactions increase the risk for ischemic stroke in the Han Hakka population.Brain and behavior · 2022Article
- Bioinformatics analysis to identify potential biomarkers and therapeutic targets for ST-segment-elevation myocardial infarction-related ischemic stroke.Frontiers in neurology · 2022Article
- Variants in matrix metalloproteinase-9 gene are associated with hemorrhagic transformation in acute ischemic stroke patients with atherothrombosis, small artery disease, and cardioembolic stroke.Brain and behavior · 2019Article
- Matrix metalloproteinase-9 gene polymorphisms are associated with ischemic stroke severity and early neurologic deterioration in patients with atrial fibrillation.Brain and behavior · 2019Observational
- Relationship between the matrix metalloproteinase-9 gene polymorphisms and ischemic stroke.International journal of clinical and experimental pathology · 2019Article
- The Role of Matrix Metalloproteinase Polymorphisms in Ischemic Stroke.International journal of molecular sciences · 2016Review
- Matrix Metalloproteinase-9 (MMP-9) Gene Polymorphism in Stroke Patients.Neuromolecular medicine · 2015Article
- Functional polymorphisms in the promoter region of MMP-2 and MMP-9 and susceptibility to obstructive sleep apnea.Scientific reports · 2015Article
- Association between matrix metalloproteinase gene polymorphisms and development of ischemic stroke.International journal of clinical and experimental pathology · 2015Article
- Genetic predisposition of stroke: understanding the evolving landscape through meta-analysis.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIschemic stroke (IS) results from interrupted blood flow to the brain and can be caused by formation of atherosclerotic plaques in blood vessels. Previous studies have suggested a contribution of matrix metalloproteinases (MMP) to plaque formation and stroke risk. Here, we explored associations between two MMPs, MMP-2 and MMP-9, and IS.
methodsThere were 396 IS patients and 400 control individuals involved in this study. The MMP-2 -1306C/T and -735C/T polymorphisms and MMP-9 -1562C/T polymorphism were analyzed by restriction fragment length polymorphism (RFLP) from patient blood samples, and the relationships to IS were analyzed by logistic regression.
resultsGenotype and allele frequencies of MMP-2 -1306C/T did not differ statistically (P>0.05), but those of MMP-2 -735C/T and MMP-9 1562C/T did differ between IS and control samples (P<0.05). While MMP-2 -1306C/T polymorphism was not associated with increased risk of IS, MMP-2 -735C allele was associated with a 1.5-fold increase in IS incidence (OR=1.516, 95% CI=1.185-1.940, P=0.001), and MMP-9 -1562T allele was associated with a 1.5-fold increase in IS incidence (OR=1.543, 95% CI=1.144-2.080, P=0.004).
conclusionMMP-2 -735C and MMP-9 -1562T may act as IS susceptibility alleles.
Indexed as
Identifiers
24600495PMC3931594W1621875477What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.