ReviewFrontiers in genetics2014
The missing story behind Genome Wide Association Studies: single nucleotide polymorphisms in gene deserts have a story to tell.
Review in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Genomic regions associated with muscularity in beef cattle differ in five contrasting cattle breeds.Genetics, selection, evolution : GSE · 2020Pooled it
- Article
- A high-density genome-wide association with absolute blood monocyte count in domestic sheep identifies novel loci.PloS one · 2022Article
- Article
- Variant to Gene Mapping to Discover New Targets for Immune Tolerance.Frontiers in immunology · 2021Article
- Exome sequencing in genetic disease: recent advances and considerations.F1000Research · 2020Review
- Whole Genome Sequence Data Provides Novel Insights Into the Genetic Architecture of Meat Quality Traits in Beef.Frontiers in genetics · 2020Article
- LncRNAs join hands together to regulate neuroblastoma progression.Molecular & cellular oncology · 2019Article
- Primary closed angle glaucoma in the Basset Hound: Genetic investigations using genome-wide association and RNA sequencing strategies.Molecular vision · 2019Article
- Realizing the significance of noncoding functionality in clinical genomics.Experimental & molecular medicine · 2018Review
- Intergenic disease-associated regions are abundant in novel transcripts.Genome biology · 2017Article
- Differential methylation is associated with non-syndromic cleft lip and palate and contributes to penetrance effects.Scientific reports · 2017Article
- Genome-wide association analysis in dogs implicates 99 loci as risk variants for anterior cruciate ligament rupture.PloS one · 2017Article
- In the loop: promoter-enhancer interactions and bioinformatics.Briefings in bioinformatics · 2016Review
- Coordinated Action of Biological Processes during Embryogenesis Can Cause Genome-Wide Linkage Disequilibrium in the Human Genome and Influence Age-Related Phenotypes.Annals of gerontology and geriatric research · 2016Article
- Seq2pathway: an R/Bioconductor package for pathway analysis of next-generation sequencing data.Bioinformatics (Oxford, England) · 2015Article
- Multiple blood pressure loci with opposing blood pressure effects on rat chromosome 1 in a homologous region linked to hypertension on human chromosome 15.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Connecting SNPs in Diabetes: A Spatial Analysis of Meta-GWAS Loci.Frontiers in endocrinology · 2015Review
- Insights from space: potential role of diet in the spatial organization of chromosomes.Nutrients · 2014Review
- Kernel-based whole-genome prediction of complex traits: a review.Frontiers in genetics · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome wide association studies are central to the evolution of personalized medicine. However, the propensity for single nucleotide polymorphisms (SNPs) to fall outside of genes means that understanding how these polymorphisms alter cellular function requires an expanded view of human genetics. Integrating the study of genome structure (chromosome conformation capture) into its function opens up new avenues of exploration. Changes in the epigenome associated with SNPs in gene deserts will allow us to define complex diseases in a much clearer manner, and usher in a new era of disease pathway exploration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.