ReviewFrontiers in psychiatry2014
Genetics, cognition, and neurobiology of schizotypal personality: a review of the overlap with schizophrenia.
Review in Frontiers in psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it, 279 citations in OpenAlex.
- Association of Schizotypy With Dimensions of Cognitive Control: A Meta-Analysis.Schizophrenia bulletin · 2018Pooled it
- Lower multisensory temporal acuity in individuals with high schizotypal traits: a web-based study.Scientific reports · 2022Trial
- Interpretation of ambiguous and unambiguous idiomatic statements in high and low schizotypal individuals.Schizophrenia research. Cognition · 2026Article
- Schizotypy and subclinical depression relate to specific trait curiosity dimensions.Scientific reports · 2026Article
- Acute technostress, schizotypal traits, and visual illusion perception in the general population.Experimental brain research · 2026Article
- Thoughts Falling Apart: Disorganized Schizotypy Specifically Predicts Both Psychotic- and Stress-Reactivity in Daily Life.Journal of personality · 2026Article
- Article
- The unique contribution of Schizotypal personality subscales to psychotic-like experiences and social-personality factors in Hong Kong community youths.Frontiers in psychiatry · 2026Article
- A Multimodal Observational Case-Control Study Exploring Gut Microbiota-Hippocampus Alterations in Individuals With High Positive Schizotypy From the General Population.Biological psychiatry global open science · 2025Article
- Speech-Gesture Matching and Schizotypal Traits: A Network Approach.Schizophrenia bulletin · 2025Article
- Neuro- and social-cognition in schizotypal personality disorder and schizophrenia: A spectrum of severity.Psychiatry research · 2025Article
- Differential Association of Schizotypy Dimensions With Brain Structural Connectivity and Moderation by Schizophrenia Polygenic Risk.Schizophrenia bulletin · 2025Article
- The Relationship Between Schizotypal Personality Traits and Temporal Discounting: The Role of the Date/Delay Effect.Schizophrenia bulletin · 2025Article
- Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life.Schizophrenia bulletin · 2025Article
- Parent-Rated Schizotypy and Clinician-Rated Psychotic Experiences in Early Adolescence as Predictors of Schizophrenia Diagnosis by Middle Adulthood.Schizophrenia bulletin · 2025Article
- Genetic Susceptibility to the Environment Moderates the Impact of Childhood Experiences on Psychotic, Depressive, and Anxiety Dimensions.Schizophrenia bulletin · 2025Article
- Reduced Visual Function in Schizotypal Traits: An Exploratory Study.Schizophrenia bulletin · 2025Article
- Functional Connectome Hierarchy in Schizotypy and Its Associations With Expression of Schizophrenia-Related Genes.Schizophrenia bulletin · 2024Article
- Autistic and schizotypal traits exhibit similarities in their impact on mentalization and adult attachment impairments: a cross-sectional study.BMC psychiatry · 2024Article
- Sleep quality mediates the association between chronotype and mental health in young Indian adults.Npj mental health research · 2024Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizotypy refers to a set of temporally stable traits that are observed in the general population and that resemble the signs and symptoms of schizophrenia. Here, we review evidence from studies on genetics, cognition, perception, motor and oculomotor control, brain structure, brain function, and psychopharmacology in schizotypy. We specifically focused on identifying areas of overlap between schizotypy and schizophrenia. Evidence was corroborated that significant overlap exists between the two, covering the behavioral brain structural and functional as well molecular levels. In particular, several studies showed that individuals with high levels of schizotypal traits exhibit alterations in neurocognitive task performance and underlying brain function similar to the deficits seen in patients with schizophrenia. Studies of brain structure have shown both volume reductions and increase in schizotypy, pointing to schizophrenia-like deficits as well as possible protective or compensatory mechanisms. Experimental pharmacological studies have shown that high levels of schizotypy are associated with (i) enhanced dopaminergic response in striatum following administration of amphetamine and (ii) improvement of cognitive performance following administration of antipsychotic compounds. Together, this body of work suggests that schizotypy shows overlap with schizophrenia across multiple behavioral and neurobiological domains, suggesting that the study of schizotypal traits may be useful in improving our understanding of the etiology of schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.