Evidence map›Paper›PMID 24600410›Full record

ArticleFrontiers in psychiatry2014

Reduced intrinsic connectivity of amygdala in adults with major depressive disorder.

Rajamannar Ramasubbu, Nithya Konduru, Filomeno Cortese, Signe Bray, Ismael Gaxiola-Valdez, Bradley Goodyear

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 4 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 4 syntheses or guidelines pooled it, 182 citations in OpenAlex.

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  7. Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rajamannar RamasubbuDepartment of Psychiatry, University of Calgary , Calgary, AB , Canada ; Department of Clinical Neuroscience, University of Calgary , Calgary, AB , Canada ; Mathison Centre for Mental Health Research and Education, University of Calgary , Calgary, AB , Canada ; Hotchkiss Brain Institute, University of Calgary , Calgary, AB , Canada.
Nithya KonduruDepartment of Psychiatry, University of Calgary , Calgary, AB , Canada.
Filomeno CorteseHotchkiss Brain Institute, University of Calgary , Calgary, AB , Canada.
Signe BrayDepartment of Radiology, University of Calgary , Calgary, AB , Canada ; Alberta Children's Hospital Research Institute , Calgary, AB , Canada.
Ismael Gaxiola-ValdezHotchkiss Brain Institute, University of Calgary , Calgary, AB , Canada.
Bradley GoodyearDepartment of Psychiatry, University of Calgary , Calgary, AB , Canada ; Department of Clinical Neuroscience, University of Calgary , Calgary, AB , Canada ; Hotchkiss Brain Institute, University of Calgary , Calgary, AB , Canada ; Department of Radiology, University of Calgary , Calgary, AB , Canada.
University of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imaging studies of major depressive disorder (MDD) have demonstrated enhanced resting-state activity of the amygdala as well as exaggerated reactivity to negative emotional stimuli relative to healthy controls (HCs). However, the abnormalities in the intrinsic connectivity of the amygdala in MDD still remain unclear. As the resting-state activity and functional connectivity (RSFC) reflect fundamental brain processes, we compared the RSFC of the amygdala between unmedicated MDD patients and HCs. Seventy-four subjects, 55 adults meeting the DSM-IV criteria for MDD and 19 HCs, underwent a resting-state 3-T functional magnetic resonance imaging scan. An amygdala seed-based low frequency RSFC map for the whole brain was generated for each group. Compared with HCs, MDD patients showed a wide-spread reduction in the intrinsic connectivity of the amygdala with a variety of brain regions involved in emotional processing and regulation, including the ventrolateral prefrontal cortex, insula, caudate, middle and superior temporal regions, occipital cortex, and cerebellum, as well as increased connectivity with the bilateral temporal poles (p < 0.05 corrected). The increase in the intrinsic connectivity of amygdala with the temporal poles was inversely correlated with symptom severity and anxiety scores. Although the directionality of connections between regions cannot be inferred from temporal correlations, the reduced intrinsic connectivity of the amygdala predominantly with regions involved in emotional processing may reflect impaired bottom-up signaling for top-down cortical modulation of limbic regions leading to abnormal affect regulation in MDD.

Indexed as

amygdaladepressionfMRIfunctional connectivityneural networks

Identifiers

PMID24600410
PMCPMC3928548
OpenAlexW2001287871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.