ArticleFrontiers in physiology2014
A quantitative perspective to the study of brain arterial remodeling of donors with and without HIV in the Brain Arterial Remodeling Study (BARS).
Article in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Chromosome 10q24.32 Variants Associate With Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study.Journal of the American Heart Association · 2023Pooled it
- Cerebral Microbleeds, Cerebral Amyloid Angiopathy, and Their Relationships to Quantitative Markers of Neurodegeneration.Neurology · 2022Pooled it
- Comparative study on efficacy of thrombolytic protocols: Dual therapy against standard tPA regimen.Biophysical journal · 2025Article
- Arterial blood stealing as a mechanism of negative BOLD response: From the steady-flow with nonlinear phase separation to a windkessel-based model.Journal of theoretical biology · 2021Review
- Role of Brain Arterial Remodeling in HIV-Associated Cerebrovascular Outcomes.Frontiers in neurology · 2021Review
- Review
- Article
- Brain vascular intima vulnerability among HIV-positive and negative individuals.AIDS (London, England) · 2018Article
- Brain Large Artery Lymphocytic Inflammation and Human Immunodeficiency Virus-Related Brain Arterial Remodeling.Journal of virology · 2018Article
- Relationship between brain large artery characteristics and their downstream arterioles.Journal of neurovirology · 2018Article
- Intracranial Atherosclerosis: From Microscopy to High-Resolution Magnetic Resonance Imaging.Journal of stroke · 2017Review
- Histological Characteristics of Intracranial Atherosclerosis in a Chinese Population: A Postmortem Study.Frontiers in neurology · 2017Article
- Metalloproteinases and Brain Arterial Remodeling Among Individuals With and Those Without HIV Infection.The Journal of infectious diseases · 2016Article
- Brain arterial aging and its relationship to Alzheimer dementia.Neurology · 2016Article
- Brain large artery inflammation associated with HIV and large artery remodeling.AIDS (London, England) · 2016Article
- Infection and Stroke: an Update on Recent Progress.Current neurology and neuroscience reports · 2016Review
- A pathological perspective on the natural history of cerebral atherosclerosis.International journal of stroke : official journal of the International Stroke Society · 2015 · on this mapArticle
- Brain arterial remodeling contribution to nonembolic brain infarcts in patients with HIV.Neurology · 2015Article
- A Functional Perspective on the Embryology and Anatomy of the Cerebral Blood Supply.Journal of stroke · 2015Review
- The National NeuroAIDS Tissue Consortium (NNTC) Database: an integrated database for HIV-related studies.Database : the journal of biological databases and curation · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Mechanisms underlying brain arterial remodeling are uncertain. We tested the hypothesis that arterial size and location are important determinants of arterial characteristics. We collected large and penetrating brain arteries from cadavers with and without HIV. Morphometric characterization was obtained from digital images using color-based thresholding. The association of arterial size and location with lumen diameter, media and adventitia area, media proportion, a wall thickness, wall-to-lumen ratio and stenosis was obtained with multilevel mixed models and a P value ≤ 0.05 was considered significant. We included 336 brains, in which 2279 large arteries and 1488 penetrating arteries were identified. We found that arterial size was significantly associated with all arterial characteristics studied of large and penetrating arteries with exception of arterial stenosis in large arteries. After adjusting for size, an independent association was found between lumen diameters, media and adventitia thickness with artery locations. Arterial stenosis was also associated with artery location in both large and penetrating arteries. In summary, significant effects of size and/or location were found in arterial characteristics typically used to define arterial remodeling. Brain arterial remodeling characteristics differ across arterial sizes and location, and these differences should be controlled for in future studies of brain arterial remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.