ArticleFrontiers in cellular neuroscience2014
Cannabinoid-dependent potentiation of inhibition at eye opening in mouse V1.
Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Layer specific regulation of critical period timing and maturation of mouse visual cortex by endocannabinoids.iScience · 2024Article
- Modulation of Coordinated Activity across Cortical Layers by Plasticity of Inhibitory Synapses.Cell reports · 2020Article
- Distinct Heterosynaptic Plasticity in Fast Spiking and Non-Fast-Spiking Inhibitory Neurons in Rat Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity.Nature reviews. Neuroscience · 2019Review
- Does experience provide a permissive or instructive influence on the development of direction selectivity in visual cortex?Neural development · 2018Review
- Emerging Mechanisms Underlying Dynamics of GABAergic Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Cortical amplification models of experience-dependent development of selective columns and response sparsification.Journal of neurophysiology · 2017Article
- Visual Stimulus Speed Does Not Influence the Rapid Emergence of Direction Selectivity in Ferret Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Optogenetic spatial and temporal control of cortical circuits on a columnar scale.Journal of neurophysiology · 2016Article
- Expression and Function of the Endocannabinoid System in the Retina and the Visual Brain.Neural plasticity · 2016Review
- The Endocannabinoid System in the Retina: From Physiology to Practical and Therapeutic Applications.Neural plasticity · 2016Review
- Competition, inhibition, and critical periods of cortical plasticity.Current opinion in neurobiology · 2015Review
- Ultrastructural evidence for synaptic contacts between cortical noradrenergic afferents and endocannabinoid-synthesizing post-synaptic neurons.Neuroscience · 2015Article
- Emerging feed-forward inhibition allows the robust formation of direction selectivity in the developing ferret visual cortex.Journal of neurophysiology · 2014Article
- Layer-specific Developmental Changes in Excitation and Inhibition in Rat Primary Visual Cortex.eNeuroArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cannabinoid (CB) signaling is a well established regulator of synaptic transmission. Recent work demonstrated that CB release is necessary for the induction of inhibitory synaptic plasticity. In primary visual cortex (V1) CB receptors are present throughout life, though their level of expression is developmentally regulated. In the input layer of V1 (layer 4, L4) these receptors show low levels of expression and colocalize with GABAergic terminals suggesting that they may play an important role in regulating GABAergic transmission. Here we show that in the developmental window extending from eye opening to the onset of the critical period for visual cortical plasticity L4 inhibitory inputs onto pyramidal neurons are highly sensitive to activation of CB release. More specifically, application of synthetic and endogenous CB receptors agonists led to a significant increase in the amplitude and frequency of both spontaneous inhibitory post-synaptic currents and miniature inhibitory post-synaptic currents. This form of inhibitory potentiation is activity-dependent, induced by repetitive bursting of pyramidal neurons and regulated by the time of eye opening. CB-dependent regulation of inhibitory drive may be a mechanism for the regulating L4 pyramidal neurons excitability and function at a time in which V1 transitions from being activated by spontaneous activity to being driven by visual inputs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.