ArticleFrontiers in cellular neuroscience2014
NanoCAGE analysis of the mouse olfactory epithelium identifies the expression of vomeronasal receptors and of proximal LINE elements.
Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Tex15 is required for vomeronasal sensory neuron diversity and male pheromone detection.bioRxiv : the preprint server for biology · 2025Article
- CD36 is expressed in a defined subpopulation of neurons in the olfactory epithelium.Scientific reports · 2016Article
- Laser capture microdissection: Big data from small samples.Histology and histopathology · 2015Review
- Mammalian pheromones: emerging properties and mechanisms of detection.Current opinion in neurobiology · 2015Review
- Editorial for "Regulatory RNAs in the nervous system".Frontiers in cellular neuroscience · 2015Article
- Functional promiscuity in a mammalian chemosensory system: extensive expression of vomeronasal receptors in the main olfactory epithelium of mouse lemurs.Frontiers in neuroanatomy · 2014Article
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
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Abstract
By coupling laser capture microdissection to nanoCAGE technology and next-generation sequencing we have identified the genome-wide collection of active promoters in the mouse Main Olfactory Epithelium (MOE). Transcription start sites (TSSs) for the large majority of Olfactory Receptors (ORs) have been previously mapped increasing our understanding of their promoter architecture. Here we show that in our nanoCAGE libraries of the mouse MOE we detect a large number of tags mapped in loci hosting Type-1 and Type-2 Vomeronasal Receptors genes (V1Rs and V2Rs). These loci also show a massive expression of Long Interspersed Nuclear Elements (LINEs). We have validated the expression of selected receptors detected by nanoCAGE with in situ hybridization, RT-PCR and qRT-PCR. This work extends the repertory of receptors capable of sensing chemical signals in the MOE, suggesting intriguing interplays between MOE and VNO for pheromone processing and positioning transcribed LINEs as candidate regulatory RNAs for VRs expression.
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