ArticleJournal of immunology (Baltimore, Md. : 1950)2014
IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 82 citations in OpenAlex.
- TNFR2 is expressed by a discrete subset of epidermal T cells with an IL-17 gene signature during psoriasis.PloS one · 2026Article
- TNFR2 is Expressed by a Discrete Subset of Epidermal γδ T Cells with an IL-17 Gene Signature during Psoriasis.bioRxiv : the preprint server for biology · 2025Article
- Hydrogen-Releasing Micromaterial Dressings: Promoting Wound Healing by Modulating Extracellular Matrix Accumulation Through Wnt/β-Catenin and TGF-β/Smad Pathways.Pharmaceutics · 2025Article
- IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression.Investigative ophthalmology & visual science · 2025Article
- Roles of dendritic epidermal T cells in steady and different pathological states.Burns & trauma · 2025Review
- Impact of obesity on the CCR6-CCL20 axis in epidermal γδ T cells and IL-17A production in murine wound healing and psoriasis.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Gut Microbiota Regulates the Homeostasis of Dendritic Epidermal T Cells.Life (Basel, Switzerland) · 2024Article
- Article
- Diminished γδ T Cells during Murine Allergic Skin Inflammation Is Mediated by IL-4 Signaling in Keratinocytes.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Impact of Obesity on the CCR6-CCL20 Axis in Epidermal γδ T Cells and IL-17A Production in Murine Wound Healing and Psoriasis.bioRxiv : the preprint server for biology · 2024Article
- IL-1Mediators of inflammation · 2023Review
- MR1 deficiency enhances IL-17-mediated allergic contact dermatitis.Frontiers in immunology · 2023Article
- Macrophages in Skin Wounds: Functions and Therapeutic Potential.Biomolecules · 2022Review
- γδ T Cells in Skin Inflammation.Critical reviews in immunology · 2022Review
- Isolation and Quantification of Mouse γδT-cellsBio-protocol · 2021Article
- Lysophosphatidylcholine aggravates contact hypersensitivity by promoting neutrophil infiltration and IL17 expression.BMB reports · 2021Article
- Vitamin D3 ameliorates nitrogen mustard-induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway.Clinical and translational medicine · 2021Article
- Epidermal resident γδ T cell development and function in skin.Cellular and molecular life sciences : CMLS · 2021Review
- Gamma Delta T Cells and Their Pathogenic Role in Psoriasis.Frontiers in immunology · 2021Review
- Skin Resident γδ T Cell Function and Regulation in Wound Repair.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Substances that penetrate the skin surface can act as allergens and induce a T cell-mediated inflammatory skin disease called contact hypersensitivity (CHS). IL-17 is a key cytokine in CHS and was originally thought to be produced solely by CD4(+) T cells. However, it is now known that several cell types, including γδ T cells, can produce IL-17. In this study, we determine the role of γδ T cells, especially dendritic epidermal T cells (DETCs), in CHS. Using a well-established model for CHS in which 2,4-dinitrofluorobenzene (DNFB) is used as allergen, we found that γδ T cells are important players in CHS. Thus, more IL-17-producing DETCs appear in the skin following exposure to DNFB in wild-type mice, and DNFB-induced ear swelling is reduced by ∼50% in TCRδ(-/-) mice compared with wild-type mice. In accordance, DNFB-induced ear swelling was reduced by ∼50% in IL-17(-/-) mice. We show that DNFB triggers DETC activation and IL-1β production in the skin and that keratinocytes produce IL-1β when stimulated with DNFB. We find that DETCs activated in vitro by incubation with anti-CD3 and IL-1β produce IL-17. Importantly, we demonstrate that the IL-1R antagonist anakinra significantly reduces CHS responses, as measured by decreased ear swelling, inhibition of local DETC activation, and a reduction in the number of IL-17(+) γδ T cells and DETCs in the draining lymph nodes. Taken together, we show that DETCs become activated and produce IL-17 in an IL-1β-dependent manner during CHS, suggesting a key role for DETCs in CHS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.