Evidence map›Paper›PMID 24599981›Full record

ArticleJournal of clinical microbiology2014

Emergence of G186D mutation in the presence of R292K mutation in an immunocompromised child infected with influenza A/H3N2 virus, treated with oseltamivir.

Hong Kai Lee, Julian Wei-Tze Tang, Tze Ping Loh, Debra Han-Lin Kong, Yew-Weng Lau, Hui Kim Yap, Evelyn Siew-Chuan Koay

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hong Kai LeeDepartment of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Julian Wei-Tze Tang
Tze Ping Loh
Debra Han-Lin Kong
Yew-Weng Lau
Hui Kim Yap
Evelyn Siew-Chuan Koay
National University Health System · SGNational University of Singapore · SGUniversity of Alberta Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An immunocompromised child with influenza A/H3N2 virus infection, treated with oseltamivir from day 1, had nasal swabs taken on days 1, 4, 7, and 10 of the illness. Pyrosequencing showed increasing proportions of viruses with R292K (neuraminidase gene) and G186D (hemagglutinin gene) mutations, resulting in a viral load rebound by day 10.

Indexed as

ChildFemaleGenes, ViralHumansImmunocompromised HostInfluenza A Virus, H3N2 SubtypeInfluenza, HumanMutationOseltamivirViral LoadOseltamivir

Identifiers

PMID24599981
PMCPMC3993657
OpenAlexW1979218536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.