ArticleJournal of clinical microbiology2014
Characterization of hepatitis delta virus in sub-Saharan Africa.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Viral hepatitis associated hepatocellular carcinoma on the African continent, the past, present, and future: a systematic review.BMC cancer · 2021Pooled it
- High prevalence of hepatitis B infections in Burkina Faso (1996-2017): a systematic review with meta-analysis of epidemiological studies.BMC public health · 2018Pooled it
- The Epidemiology of Hepatitis D Virus in North Africa: A Systematic Review and Meta-Analysis.TheScientificWorldJournal · 2018Pooled it
- Prevalence of hepatitis D virus infection in sub-Saharan Africa: a systematic review and meta-analysis.The Lancet. Global health · 2017Pooled it
- High prevalence of hepatitis delta virus in Cameroon.Scientific reports · 2018Trial
- Article
- Hepatitis delta virus co-infection in patients with hepatocellular carcinoma and people living with HIV in Nigeria.BMC infectious diseases · 2026Article
- Hepatitis D epidemiology and access to diagnostic testing among healthcare providers in Africa: A multi-country survey.JHEP reports : innovation in hepatology · 2025Article
- Seroprevalence and molecular characterization of viral hepatitis and HIV co-infection in the Central African Republic.PloS one · 2024Article
- [Delta hepatitis in Africa: epidemiological and clinical particularities].Medecine tropicale et sante internationale · 2023Review
- Combination of Novel Therapies for HDV.Viruses · 2022Review
- Low prevalence of hepatitis delta infection in Cuban HBsAg carriers: Prospect for elimination.Frontiers in medicine · 2022Article
- Prevalence and characteristics of hepatitis B and D virus infections among HIV-positive individuals in Southwestern Nigeria.Virology journal · 2021Article
- Author Correction: Development and performance of prototype serologic and molecular tests for hepatitis delta infection.Scientific reports · 2020Article
- Chronic hepatitis delta: A state-of-the-art review and new therapies.World journal of gastroenterology · 2019Review
- Evolutionary trends in the prevalence of anti-HDV antibodies among patients positive for HBsAg referred to a national laboratory in Cameroon from 2012 to 2017.BMC research notes · 2019Article
- Pathogenesis of and New Therapies for Hepatitis D.Gastroenterology · 2019Review
- First study of hepatitis delta virus in Algeria: Seroprevalence and risk factors in Setif region (east of Algeria).Southern African journal of infectious diseases · 2019Article
- Hepatitis B, C, and D virus and human T-cell leukemia virus types 1 and 2 infections and correlates among men who have sex with men in Ouagadougou, Burkina Faso.Virology journal · 2018Article
- HDV infection rates in northern Vietnam.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis D virus (HDV) is a satellite of hepatitis B virus (HBV), and infection with this virus aggravates acute and chronic liver disease. While HBV seroprevalence is very high across sub-Saharan Africa, much less is known about HDV in the region. In this study, almost 2,300 blood serum samples from Burkina Faso (n=1,131), Nigeria (n=974), Chad (n=50), and the Central African Republic (n = 118) were screened for HBV and HDV. Among 743 HBsAg-positive serum samples, 74 were positive for HDV antibodies and/or HDV RNA, with considerable differences in prevalence, ranging from <2% (pregnant women from Burkina Faso) to 50% (liver patients from Central African Republic). HDV seems to be much more common in chronic liver disease patients in the Central African Republic (CAR) than in similar cohorts in Nigeria. In a large nested mother-child cohort in Burkina Faso, the prevalence of HDV antibodies was 10 times higher in the children than in their mothers, despite similar HBsAg prevalences, excluding vertical transmission as an important route of infection. The genotyping of 16 full-length and 8 partial HDV strains revealed clade 1 (17/24) in three of the four countries, while clades 5 (5/24) and 6 (2/24) were, at least in this study, confined to Central Nigeria. On the amino acid level, almost all our clade 1 strains exhibited a serine at position 202 in the hepatitis D antigen, supporting the hypothesis of an ancient African HDV-1 subgroup. Further studies are required to understand the public health significance of the highly varied HDV prevalences in different cohorts and countries in sub-Saharan Africa.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.