ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2014
Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Loss of KDM5A-mediated H3K4me3 demethylation promotes aberrant neural development by Wnt/β-catenin pathway activation.Cell death & disease · 2025Article
- Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation.Cell communication and signaling : CCS · 2025Article
- Frizzled receptors: gatekeepers of Wnt signaling in development and disease.Frontiers in cell and developmental biology · 2025Review
- The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border.Development (Cambridge, England) · 2023Article
- FZD10 regulates cell proliferation and mediates Wnt1 induced neurogenesis in the developing spinal cord.PloS one · 2020Article
- Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea.Investigative ophthalmology & visual science · 2019Article
- Fatty acid recognition in the Frizzled receptor family.The Journal of biological chemistry · 2019Review
- The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development.Frontiers in molecular neuroscience · 2017Article
- Divergent effects of Porcupine and Wntless on WNT1 trafficking, secretion, and signaling.Experimental cell research · 2016Article
- Inhibition of canonical WNT/β-catenin signaling is involved in leflunomide (LEF)-mediated cytotoxic effects on renal carcinoma cells.Oncotarget · 2016Article
- microRNA regulation of Wnt signaling pathways in development and disease.Cellular signalling · 2015Review
- Concentration-dependent effects of WNTLESS on WNT1/3A signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWNT1 and WNT3A drive a dorsal to ventral gradient of β-catenin-dependent Wnt signaling in the developing spinal cord. However, the identity of the receptors mediating downstream functions remains poorly understood.
resultsIn this report, we show that the spatiotemporal expression patterns of FZD10 and WNT1/WNT3A are highly correlated. We further show that in the presence of LRP6, FZD10 promotes WNT1 and WNT3A signaling using an 8xSuperTopFlash reporter assay. Consistent with a functional role for FZD10, we demonstrate that FZD10 is required for proliferation in the spinal cord. Finally, by using an in situ proximity ligation assay, we observe an interaction between FZD10 and WNT1 and WNT3A proteins.
conclusionsTogether, our results identify FZD10 as a receptor for WNT1 and WNT3A in the developing chick spinal cord.
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