ReviewJournal of biochemical and molecular toxicology2014
The perplexing paradox of paraquat: the case for host-based susceptibility and postulated neurodegenerative effects.
Review in Journal of biochemical and molecular toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- A novel rat model of body first subtype of Parkinson's disease.bioRxiv : the preprint server for biology · 2026Article
- The effects of crocin nanoparticle on trace elements levels in paraquat-induced oxidative stress in rat.Scientific reports · 2026Article
- HFE H63D Limits Nigral Vulnerability to Paraquat in Agricultural Workers.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Paraquat Toxicogenetics: Strain-Related Reduction of Tyrosine Hydroxylase Staining inFrontiers in toxicology · 2021Article
- Pesticide use and incident Parkinson's disease in a cohort of farmers and their spouses.Environmental research · 2020Article
- Systems Genetics and Systems Biology Analysis of Paraquat Neurotoxicity in BXD Recombinant Inbred Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Environmental neurotoxicant-induced dopaminergic neurodegeneration: a potential link to impaired neuroinflammatory mechanisms.Pharmacology & therapeutics · 2019Review
- Modification of Wnt signaling pathway on paraquat-induced inhibition of neural progenitor cell proliferation.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Response to: Neurotoxicity of paraquat and paraquat-induced Parkinson's disease.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- Synergistic stress exacerbation in hippocampal neurons: Evidence favoring the dual-hit hypothesis of neurodegeneration.Hippocampus · 2016Article
- Of Pesticides and Men: a California Story of Genes and Environment in Parkinson's Disease.Current environmental health reports · 2016Review
- Article
- Parkinson's Disease: The Mitochondria-Iron Link.Parkinson's disease · 2016Review
- Toxicogenetics: in search of host susceptibility to environmental toxicants.Frontiers in genetics · 2014Review
Corrections and comments
- Commented on by
- Commented on byResponse.2014
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Paraquat is an herbicide used extensively in agriculture and has also been proposed to be a risk factor for Parkinson's disease. To date, experimental, clinical, and epidemiological data on paraquat neurotoxicity have been equivocal. In this short review, we discuss some technical and biological mechanisms that contribute to inconsistencies regarding paraquat neurotoxicity. We hypothesize that individual genetic variations in susceptibility generate major differences in neurotoxic risk and functional outcome. Identifying these heritable sources of variation in host susceptibility, and their role in complex gene-environment interactions, is crucial to identify risk biomarkers and to devise better prevention and treatment for those exposed to paraquat and other potential neurotoxicants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.