ReviewCurrent osteoporosis reports2014
Fat and bone interactions.
Review in Current osteoporosis reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia.Journal of bone and mineral metabolism · 2017Trial
- Longitudinal assessment of oxytocin efficacy on bone and bone marrow fat masses in a rabbit osteoporosis model through 3.0-T magnetic resonance spectroscopy and micro-CT.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Trial
- Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases.Signal transduction and targeted therapy · 2026Review
- Effects of Lipid Metabolites and Cross Organ Lipid Metabolism Regulation on Bone Homeostasis.Aging and disease · 2025Review
- Preoperative Prediction of New Vertebral Fractures after Vertebral Augmentation with a Radiomics Nomogram.Diagnostics (Basel, Switzerland) · 2023Article
- Vertebral bone quality different in magnetic resonance imaging parameters.Journal of orthopaedic surgery and research · 2023Article
- Soluble epoxide hydrolase inhibitor can protect the femoral head against tobacco smoke exposure-induced osteonecrosis in spontaneously hypertensive rats.Toxicology · 2022Article
- Bone marrow adipose tissue content in Latino adolescents with prediabetes and obesity.Obesity (Silver Spring, Md.) · 2021Article
- Voxel-based mapping of five MR biomarkers in the wrist bone marrow.Magma (New York, N.Y.) · 2021Article
- Abnormal Lipid Profile in Fast-Growing Broilers With Spontaneous Femoral Head Necrosis.Frontiers in physiology · 2021Article
- Differences between muscle from osteoporotic and osteoarthritic subjects: in vitro study by diffusion-tensor MRI and histological findings.Aging clinical and experimental research · 2020Article
- Dairy product intake decreases bone resorption following a 12-week diet and exercise intervention in overweight and obese adolescent girls.Pediatric research · 2020Article
- Pregnancy and lactation, a challenge for the skeleton.Endocrine connections · 2020Review
- Diffusion MRI for Assessment of Bone Quality; A Review of Findings in Healthy Aging and Osteoporosis.Journal of magnetic resonance imaging : JMRI · 2020Review
- Increased NF-kB activity in osteoprogenitor-lineage cells impairs the balance of bone versus fat in the marrow of skeletally mature mice.Regenerative engineering and translational medicine · 2020Article
- Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness.Pediatric research · 2020Article
- Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population.Mediators of inflammation · 2020Article
- MicroRNA-130a controls bone marrow mesenchymal stem cell differentiation towards the osteoblastic and adipogenic fate.Cell proliferation · 2019Article
- Lipid profiles as potential mediators linking body mass index to osteoporosis among Chinese adults: the Henan Rural Cohort Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Therapeutic approaches to osteosarcopenia: insights for the clinician.Therapeutic advances in musculoskeletal disease · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fat and bone have a complicated relationship. Although obesity has been associated with low fracture risk, there is increasing evidence that some of the factors that are released by peripheral fat into the circulation may also have a deleterious effect on bone mass, thus, predisposing to fractures. More importantly, the local interaction between fat and bone within the bone marrow seems to play a significant role in the pathogenesis of age-related bone loss and osteoporosis. This "local interaction" occurs inside the bone marrow and is associated with the autocrine and paracrine release of fatty acids and adipokines, which affect the cells in their vicinity including the osteoblasts, reducing their function and survival. In this review, we explore the particularities of the fat and bone cell interactions within the bone marrow, their significance in the pathogenesis of osteoporosis, and the potential therapeutic applications that regulating marrow fat may have in the near future as a novel pharmacologic treatment for osteoporosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.