ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Murine arcuate nucleus kisspeptin neurons communicate with GnRH neurons in utero.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 79 citations in OpenAlex.
- PCOS-like phenotype in rats after intrauterine EV exposure: puberty and adulthood.Endocrine connections · 2026Article
- Knockout of PI4-Kinase A in GnRH Neurons Causes their Prepubertal Death.bioRxiv : the preprint server for biology · 2026Article
- PI4-kinase A is essential for survival of the GnRH neurons.Frontiers in endocrinology · 2026Article
- Neuronal plasticity at puberty in mouse hypothalamicProceedings of the National Academy of Sciences of the United States of America · 2025Article
- KNDy Neurons and the Control of the Gonadotropic Axis in the Midgestation Fetal Sheep.Endocrinology · 2025Article
- Transcriptomic profiling of murine GnRH neurons reveals developmental trajectories linked to human reproduction and infertility.Theranostics · 2025Article
- Selective depletion of kisspeptin neurons in the hypothalamic arcuate nucleus in early juvenile life reduces pubertal LH secretion and delays puberty onset in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Developmental sex differences in the peri-pubertal pattern of hypothalamic reproductive gene expression, including Kiss1 and Tac2, may contribute to sex differences in puberty onset.Molecular and cellular endocrinology · 2022Article
- The electrophysiologic properties of gonadotropin-releasing hormone neurons.Journal of neuroendocrinology · 2022Review
- Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling.Annual review of physiology · 2022Review
- The GnRH Antagonist Degarelix Suppresses Gonadotropin Secretion and Pituitary Sensitivity in Midgestation Sheep Fetuses.Endocrinology · 2022Article
- Prenatal androgen treatment impairs the suprachiasmatic nucleus arginine-vasopressin to kisspeptin neuron circuit in female mice.Frontiers in endocrinology · 2022Article
- Reproductive Deficits Induced by Prenatal Antimüllerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells.Endocrinology · 2021Article
- Sexually Dimorphic Neurosteroid Synthesis Regulates Neuronal Activity in the Murine Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Prolactin-sensitive olfactory sensory neurons regulate male preference in female mice by modulating responses to chemosensory cues.Science advances · 2021Article
- Central precocious puberty: Recent advances in understanding the aetiology and in the clinical approach.Clinical endocrinology · 2021Review
- Deficiency of arcuate nucleus kisspeptin results in postpubertal central hypogonadism.American journal of physiology. Endocrinology and metabolism · 2021Article
- Puberty, A Sensitive Window of Hypothalamic Development and Plasticity.Endocrinology · 2021Review
- Metabolic regulation of kisspeptin - the link between energy balance and reproduction.Nature reviews. Endocrinology · 2020Review
- Programmed for Preference: The Biology of Same-Sex Attraction in Rams.Neuroscience and biobehavioral reviews · 2020Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Puberty is a transition period of reproductive development from juvenile stages to adulthood and depends upon the activity of gonadotropin-releasing hormone (GnRH) neurons. GnRH neurons are initially activated in utero but remain quiescent throughout the juvenile period. Premature reactivation of GnRH neurons results in precocious puberty in mice and humans, but the mechanisms underlying developmental control of GnRH neuron activity remain unknown. The neuropeptide kisspeptin, a potent activator of GnRH neurons that is implicated as a critical permissive signal triggering puberty and a major regulator of the adult female hypothalamus-pituitary-gonadal axis, is paradoxically produced by neurons in the developing brain well before puberty onset. Thus, the neural circuits controlling the timing of reproductive maturation remain elusive. Here, we delineate the underlying neural circuitry using conditional genetic transsynaptic tracing in female mouse embryos. We find that kisspeptin-producing neurons in the arcuate nucleus (ARC) already communicate with a specific subset of GnRH neurons in utero. We show that ARC kisspeptin neurons are upstream of GnRH neurons, and that GnRH neuron connectivity to ARC kisspeptin neurons does not depend on their spatial position in the brain. Furthermore, we demonstrate that the neural circuits between ARC kisspeptin and GnRH neurons are fully established and operative before birth. Finally, we find that most GnRH neurons express the kisspeptin receptor GPR54 upon circuit formation, suggesting that the signaling system implicated in gatekeeping puberty becomes operative in the embryo.
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