Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Compensatory changes accompanying chronic forced use of the nondominant hand by unilateral amputees.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationship between chronic pain and brain reorganization after deafferentation: A systematic review of functional MRI findings.NeuroImage. Clinical · 2015Pooled it
- Brain lateralization in children with upper-limb reduction deficiency.Journal of neuroengineering and rehabilitation · 2021Trial
- Blocking tactile input to one finger using anaesthetic enhances touch perception and learning in other fingers.Journal of experimental psychology. General · 2019Trial
- Visual feedback alters force control and functional activity in the visuomotor network after stroke.NeuroImage. Clinical · 2018Trial
- Functional connectivity during drawing after upper extremity peripheral nerve surgery: enhanced connectivity between motor and visuomotor-parietal regions.bioRxiv : the preprint server for biology · 2026Article
- From Amputation to Persistent Pain: A Review of Molecular and Cellular Processes in Phantom Limb Pain.International journal of molecular sciences · 2026Review
- Identifying left and right hemispheres using functional connectivity.bioRxiv : the preprint server for biology · 2025Article
- Brain activation for actual and imagined hand movement following bilateral hand transplantation.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Neural mechanisms of handedness for precision drawing: hand-dependent engagement of cortical networks for bimanual control and tool use.bioRxiv : the preprint server for biology · 2025Article
- Effect of practice on the control of reach extent.Experimental brain research · 2025Article
- Reducing Inter-Individual Differences in Task fMRI Preprocessing with OGRE (One-Step General Registration and Extraction) Preprocessing.Neuroinformatics · 2025Article
- Prevalence of left-handers and their role in antagonistic sports: beyond mere counts towards a more in-depth distributional analysis of ranking data.Royal Society open science · 2025Article
- Block Building Task Identifies Distinct Groups of Left/Right-hand Choice Patterns After Unilateral Peripheral Nerve Injury.Journal of visualized experiments : JoVE · 2025Article
- Changes in hemispheric dominance following targeted muscle reinnervation: a case study.Frontiers in human neuroscience · 2025Article
- The neurophysiology of sensorimotor prosthetic control.BMC biomedical engineering · 2024Review
- Reducing individual differences in task fMRI with OGRE (One-step General Registration and Extraction) preprocessing.bioRxiv : the preprint server for biology · 2024Article
- Healthy adults favor stable left/right hand choices over performance at an unconstrained reach-to-grasp task.Experimental brain research · 2024Article
- Roles of Handedness and Hemispheric Lateralization: Implications for Rehabilitation of the Central and Peripheral Nervous Systems: A Rapid Review.The American journal of occupational therapy : official publication of the American Occupational Therapy Association · 2024Review
- Patient Outcomes After Peripheral Nerve Injury Depend on Bimanual Dexterity and Preserved Use of the Affected Hand.Neurorehabilitation and neural repair · 2024Article
- Does Ipsilateral Remapping Following Hand Loss Impact Motor Control of the Intact Hand?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Amputation of the dominant hand forces patients to use the nondominant hand exclusively, including for tasks (e.g., writing and drawing) that were formerly the sole domain of the dominant hand. The behavioral and neurological effects of this chronic forced use of the nondominant hand remain largely unknown. Yet, these effects may shed light on the potential to compensate for degradation or loss of dominant hand function, as well as the mechanisms that support motor learning under conditions of very long-term training. We used a novel precision drawing task and fMRI to investigate 8 adult human amputees with chronic (mean 33 years) unilateral dominant (right) hand absence, and right-handed matched controls (8 for fMRI, 19 for behavior). Amputees' precision drawing performances with their left hands reached levels of smoothness (associated with left hemisphere control), acceleration time (associated with right hemisphere control), and speed equivalent to controls' right hands, whereas accuracy maintained a level comparable with controls' left hands. This compensation is supported by an experience-dependent shift from heavy reliance on the dorsodorsal parietofrontal pathway (feedback control) to the ventrodorsal pathway and prefrontal regions involved in the cognitive control of goal-directed actions. Relative to controls, amputees also showed increased activity within the former cortical sensorimotor hand territory in the left (ipsilateral) hemisphere. These data demonstrate that, with chronic and exclusive forced use, the speed and quality of nondominant hand precision endpoint control in drawing can achieve levels nearly comparable with the dominant hand.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.