ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Aberrant development and plasticity of excitatory visual cortical networks in the absence of cpg15.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
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- Neuritin: a multifaceted neuroprotective factor with emerging applications for neurodegeneration.Frontiers in neuroscience · 2025Review
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- Integrated Proteomics to Understand the Role of Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer's Disease.Molecular & cellular proteomics : MCP · 2023Article
- Establishment and Functional Characterization of Murine Monoclonal Antibodies Recognizing Neuritin.Antibodies (Basel, Switzerland) · 2023Article
- Uncovering the Achilles heel of genetic heterogeneity: machine learning-based classification and immunological properties of necroptosis clusters in Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- The nonclassical MHC class I Qa-1 expressed in layer 6 neurons regulates activity-dependent plasticity via microglial CD94/NKG2 in the cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- CPG15/Neuritin Mimics Experience in Selecting Excitatory Synapses for Stabilization by Facilitating PSD95 Recruitment.Cell reports · 2019Article
- p75 Neurotrophin Receptor Activation Regulates the Timing of the Maturation of Cortical Parvalbumin Interneuron Connectivity and Promotes Juvenile-like Plasticity in Adult Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking.Cellular and molecular life sciences : CMLS · 2019Review
- Functions and the related signaling pathways of the neurotrophic factor neuritin.Acta pharmacologica Sinica · 2018Review
- Neural architecture: from cells to circuits.Journal of neurophysiology · 2018Review
- Article
- Neuritin 1 expression in human normal tissues and its association with various human cancers.International journal of clinical and experimental pathology · 2018Article
- Effect of 1.8 GHz radiofrequency electromagnetic radiation on novel object associative recognition memory in mice.Scientific reports · 2017Article
- Genetic Networks in Mouse Retinal Ganglion Cells.Frontiers in genetics · 2016Article
- Article
- Neuritin can normalize neural deficits of Alzheimer's disease.Cell death & disease · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
During development, experience plays a crucial role in sculpting neuronal connections. Patterned neural activity guides formation of functional neural circuits through the selective stabilization of some synapses and the pruning of others. Activity-regulated factors are fundamental to this process, but their roles in synapse stabilization and maturation is still poorly understood. CPG15, encoded by the activity-regulated gene candidate plasticity gene 15, is a small, glycosylphosphatidylinositol (GPI)-linked, extracellular protein that promotes synapse stabilization. Here we show that global knock-out of cpg15 results in abnormal postnatal development of the excitatory network in visual cortex and an associated disruption in development of visual receptive field properties. In addition, whereas repeated stimulation induced potentiation and depression in wild-type mice, the depression was slower in cpg15 knock-out mice, suggesting impairment in short-term depression-like mechanisms. These findings establish the requirement for cpg15 in activity-dependent development of the visual system and demonstrate the importance of timely excitatory network development for normal visual function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.