ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Normal distribution of VGLUT1 synapses on spinal motoneuron dendrites and their reorganization after nerve injury.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Meta-analysis of biological variables' impact on spinal motoneuron electrophysiology data.Journal of neurophysiology · 2020Pooled it
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- Targeting Glutamate Excitotoxicity With Memantine Modulates Glial Response and Protects Motoneurons After Spinal Root Lesion.Journal of neurochemistry · 2026Article
- Information flow drives localized morphological differences across neuronal and glial cell types.Frontiers in computational neuroscience · 2026Article
- Synaptic imbalance and increased inhibition impair motor function in SMA.Science advances · 2025Article
- An assessment of co-contraction in reinnervated muscle.Regenerative medicine · 2024Article
- Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia.Cell reports · 2024Article
- Brief Electrical Stimulation Promotes Recovery after Surgical Repair of Injured Peripheral Nerves.International journal of molecular sciences · 2024Review
- Location analysis of presynaptically active and silent synapses in single-cultured hippocampal neurons.Frontiers in neural circuits · 2024Article
- Serotonergic dysfunction impairs locomotor coordination in spinal muscular atrophy.Brain : a journal of neurology · 2023Article
- Neuronal branching is increasingly asymmetric near synapses, potentially enabling plasticity while minimizing energy dissipation and conduction time.Journal of the Royal Society, Interface · 2023Article
- Structural Preservation Does Not Ensure Function at Sensory Ia-Motoneuron Synapses following Peripheral Nerve Injury and Repair.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Aging alters mechanisms underlying voluntary movements in spinal motor neurons of mice, primates, and humans.JCI insight · 2023Article
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- Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons.EMBO molecular medicine · 2022Article
- How axon and dendrite branching are guided by time, energy, and spatial constraints.Scientific reports · 2022Article
- Trigeminal Sensory Supply Is Essential for Motor Recovery after Facial Nerve Injury.International journal of molecular sciences · 2022Review
- Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Peripheral nerve injury induces permanent alterations in spinal cord circuitries that are not reversed by regeneration. Nerve injury provokes the loss of many proprioceptive IA afferent synapses (VGLUT1-IR boutons) from motoneurons, the reduction of IA EPSPs in motoneurons, and the disappearance of stretch reflexes. After motor and sensory axons successfully reinnervate muscle, lost IA VGLUT1 synapses are not re-established and the stretch reflex does not recover; however, electrically evoked EPSPs do recover. The reasons why remaining IA synapses can evoke EPSPs on motoneurons, but fail to transmit useful stretch signals are unknown. To better understand changes in the organization of VGLUT1 IA synapses that might influence their input strength, we analyzed their distribution over the entire dendritic arbor of motoneurons before and after nerve injury. Adult rats underwent complete tibial nerve transection followed by microsurgical reattachment and 1 year later motoneurons were intracellularly recorded and filled with neurobiotin to map the distribution of VGLUT1 synapses along their dendrites. We found in control motoneurons an average of 911 VGLUT1 synapses; ~62% of them were lost after injury. In controls, VGLUT1 synapses were focused to proximal dendrites where they were grouped in tight clusters. After injury, most synaptic loses occurred in the proximal dendrites and remaining synapses were declustered, smaller, and uniformly distributed throughout the dendritic arbor. We conclude that this loss and reorganization renders IA afferent synapses incompetent for efficient motoneuron synaptic depolarization in response to natural stretch, while still capable of eliciting EPSPs when synchronously fired by electrical volleys.
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Registered trials
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