ArticleInternational journal of cancer2014
Changes in mammographic density over time in breast cancer cases and women at high risk for breast cancer.
Article in International journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Repeated measures of mammographic density and texture to evaluate prediction and risk of breast cancer: a systematic review of the methods used in the literature.Cancer causes & control : CCC · 2023Pooled it
- Chemoprevention Agents to Reduce Mammographic Breast Density in Premenopausal Women: A Systematic Review of Clinical Trials.JNCI cancer spectrum · 2021Pooled it
- Relationship Between Breast Density and Selective Estrogen-Receptor Modulators, Aromatase Inhibitors, Physical Activity, and Diet: A Systematic Review.Integrative cancer therapies · 2016Pooled it
- Randomized Double-Blind Placebo-Controlled Biomarker Modulation Study of Vitamin D Supplementation in Premenopausal Women at High Risk for Breast Cancer (SWOG S0812).Cancer prevention research (Philadelphia, Pa.) · 2019Trial
- Assessing mammographic density change within individuals across screening rounds using deep learning-based software.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Trajectories of breast density change over time and subsequent breast cancer risk: longitudinal study.BMJ (Clinical research ed.) · 2024Article
- Longitudinal history of mammographic breast density and breast cancer risk by familial risk, menopausal status, and initial mammographic density level in a high risk cohort: a nested case-control study.Breast cancer research : BCR · 2024Article
- Development and evaluation of a method to assess breast cancer risk using a longitudinal history of mammographic density: a cohort study.Breast cancer research : BCR · 2023Article
- Changes in mammographic density and risk of breast cancer among a diverse cohort of women undergoing mammography screening.Breast cancer research and treatment · 2023Article
- The FEDRA Longitudinal Study: Repeated Volumetric Breast Density Measures and Breast Cancer Risk.Cancers · 2023Article
- Factors Associated with Longitudinal Changes in Mammographic Density in a Multiethnic Breast Screening Cohort of Postmenopausal Women.The breast journal · 2023Article
- Mammographic Density Changes over Time and Breast Cancer Risk: A Systematic Review and Meta-Analysis.Cancers · 2021Review
- Adolescent and early adulthood inflammation-associated dietary patterns in relation to premenopausal mammographic density.Breast cancer research : BCR · 2021Article
- Mammography features for early markers of aggressive breast cancer subtypes and tumor characteristics: A population-based cohort study.International journal of cancer · 2021Article
- Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research.Breast cancer research : BCR · 2019Review
- Long-term excess risk of breast cancer after a single breast density measurement.European journal of cancer (Oxford, England : 1990) · 2019Article
- Longitudinal Changes in Volumetric Breast Density in Healthy Women across the Menopausal Transition.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Exploring the Role of Breast Density on Cancer Prognosis among Women Attending Population-Based Screening Programmes.Journal of oncology · 2019Article
- Breast Cancer Risk and Progressive Histology in Serial Benign Biopsies.Journal of the National Cancer Institute · 2017Article
- Aspirin use is associated with lower mammographic density in a large screening cohort.Breast cancer research and treatment · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
High mammographic breast density is one of the strongest intermediate markers of breast cancer risk, and decreases in density over time have been associated with decreases in breast cancer risk. Using repeated measures of mammographic density in a cohort of high-risk women, the Women at Risk (WAR) cohort at Columbia University Medical Center (N = 2670), we examined whether changes in prediagnostic mammographic density differed among 85 prospectively-ascertained breast cancer cases and 85 age-matched controls, using a nested case-control design. Median age at first mammogram was 51 years (range, 29-77 years), with a median of 4 years between first and second prediagnostic mammogram (range, 1-15 years). Using linear regression with change in percent density as the outcome, we found that in women who did not go on to be diagnosed with breast cancer, change in percent density decreased as time between first and second mammogram increased (β = -1.62% per year, p = 0.004). However, in women who did go on to be diagnosed with breast cancer, there was no overall change in percent density associated with time between first and second mammogram (β = 0.29% per year, p = 0.61); the change over time was statistically significantly different between cases versus controls (p <0.009). If replicated in larger cohorts, these results suggest that within-individual changes in mammographic density as measured by percent density may be a useful biomarker of breast cancer risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.