ArticlePloS one2014
Polycomb binding precedes early-life stress responsive DNA methylation at the Avp enhancer.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Exploring the roles of conserved context-dependent cis-regulatory elements (cdCREs) in multicellularity, human health and disease.The FEBS journal · 2025Review
- Metabolic memory: mechanisms and diseases.Signal transduction and targeted therapy · 2024Review
- The adipose tissue keeps the score: priming of the adrenal-adipose tissue axis by early life stress predisposes women to obesity and cardiometabolic risk.Frontiers in endocrinology · 2024Review
- Genome-Environment Interactions and Psychiatric Disorders.Biomedicines · 2023Review
- Evaluating Methylation of the Oxytocin Receptor Gene and the Oxytocin Intergenic Region.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The relevance of polycomb group proteins to the development of psychiatric disorders.Frontiers in cell and developmental biology · 2022Article
- Harsh Parenting Predicts Novel HPA Receptor Gene Methylation and NR3C1 Methylation Predicts Cortisol Daily Slope in Middle Childhood.Cellular and molecular neurobiology · 2021Article
- DNA Methyltransferases in Depression: An Update.Frontiers in psychiatry · 2020Review
- Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus.Clinical epigenetics · 2019Article
- Social Behaviour and Epigenetic Status in Adolescent and Adult Rats: The Contribution of Early-Life Stressful Social Experience.Cellular and molecular neurobiology · 2019Article
- Genomic and epigenomic mechanisms of glucocorticoids in the brain.Nature reviews. Endocrinology · 2017Review
- DNA methylation, early life environment, and health outcomes.Pediatric research · 2016Review
- Review
- Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders.Clinical epigenetics · 2015Review
- Long-term effects of early-life caregiving experiences on brain-derived neurotrophic factor histone acetylation in the adult rat mPFC.Stress (Amsterdam, Netherlands) · 2015Article
- Molecular epigenetic switches in neurodevelopment in health and disease.Frontiers in behavioral neuroscience · 2015Review
- The long-term impact of adverse caregiving environments on epigenetic modifications and telomeres.Frontiers in behavioral neuroscience · 2015Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early-life stress (ELS) in mice causes sustained hypomethylation at the downstream Avp enhancer, subsequent overexpression of hypothalamic Avp and increased stress responsivity. The sequence of events leading to Avp enhancer methylation is presently unknown. Here, we used an embryonic stem cell-derived model of hypothalamic-like differentiation together with in vivo experiments to show that binding of polycomb complexes (PcG) preceded the emergence of ELS-responsive DNA methylation and correlated with gene silencing. At the same time, PcG occupancy associated with the presence of Tet proteins preventing DNA methylation. Early hypothalamic-like differentiation triggered PcG eviction, DNA-methyltransferase recruitment and enhancer methylation. Concurrently, binding of the Methyl-CpG-binding and repressor protein MeCP2 increased at the enhancer although Avp expression during later stages of differentiation and the perinatal period continued to increase. Overall, we provide evidence of a new role of PcG proteins in priming ELS-responsive DNA methylation at the Avp enhancer prior to epigenetic programming consistent with the idea that PcG proteins are part of a flexible silencing system during neuronal development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.