Evidence map›Paper›PMID 24599278›Full record

ReviewMolecular therapy : the journal of the American Society of Gene Therapy2014

Gold nanoparticles for nucleic acid delivery.

Ya Ding, Ziwen Jiang, Krishnendu Saha, Chang Soo Kim, Sung Tae Kim, Ryan F Landis, Vincent M Rotello

Abstract readReview
In one paragraph

Review in Molecular therapy : the journal of the American Society of Gene Therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 199 papers.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

199 citing papers in PubMed.

  1. Review
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  11. PEG-NHInternational journal of nanomedicine · 2026
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Delivery of Nucleic Acids for Vascular Tissue Engineering Applications.Regenerative engineering and translational medicine · 2025
    Article
  19. Review
  20. Review

139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ya DingDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA; Department of Pharmaceutical Analysis, Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing, Jiangsu, China.
Ziwen JiangDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA.
Krishnendu SahaDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA.
Chang Soo KimDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA.
Sung Tae KimDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA.
Ryan F LandisDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA.
Vincent M RotelloDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA. Electronic address: rotello@chem.umass.edu.

Funding

Intracellular Host-Guest Activation of Nanoparticle TherapeuticsR01EB014277 · NIBIB · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTELLO, VINCENT M. · 2012 to 2014
$1.0M
NIBIB NIH HHS EB014277NIBIB NIH HHS R01 EB014277
6 · The paper itself

Abstract

Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies. We also discuss challenges in nucleic acid delivery, including endosomal entrapment/escape and active delivery/presentation of nucleic acids in the cell.

Indexed as

Drug Delivery SystemsGenetic TherapyGoldHumansMetal NanoparticlesModels, MolecularNucleic AcidsGoldNucleic Acids

Identifiers

PMID24599278
PMCPMC4048892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.