ReviewMolecules and cells2014
Tumour suppressor mechanisms in the control of chromosome stability: insights from BRCA2.
Review in Molecules and cells, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- A BRCA2 germline mutation and high expression of immune checkpoints in a TNBC patient.Cell death discovery · 2023Article
- Single-Stranded DNA Binding Proteins and Their Identification Using Machine Learning-Based Approaches.Biomolecules · 2022Review
- Expression and clinical significance of NUF2 in kidney renal clear cell carcinoma.Translational andrology and urology · 2021Article
- A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.Cell chemical biology · 2021Article
- Review
- Review
- Synthetic Lethal Activity of Benzophenanthridine Alkaloids FromFrontiers in pharmacology · 2020Article
- The role of BRCA1/2 in hereditary and familial breast and ovarian cancers.Molecular genetics & genomic medicine · 2019Review
- [Expression of NUF2 in breast cancer and its clinical significance].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Genotypic and Phenotypic Variables Affect Meiotic Cell Cycle Progression, Tumor Ploidy, and Cancer-Associated Mortality in aJournal of oncology · 2019Article
- Mutations in BRCA2 and taxane resistance in prostate cancer.Scientific reports · 2017Article
- Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer.Molecular oncology · 2016Article
- Design, synthesis, and characterization of BRC4 mutants based on the crystal structure of BRC4-RAD51(191-220).Journal of molecular modeling · 2015Article
- Cellular retinoic acid-binding protein 2 inhibits tumor growth by two distinct mechanisms.The Journal of biological chemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is unique amongst human diseases in that its cellular manifestations arise and evolve through the acquisition of somatic alterations in the genome. In particular, instability in the number and structure of chromosomes is a near-universal feature of the genomic alterations associated with epithelial cancers, and is triggered by the inactivation of tumour suppressor mechanisms that preserve chromosome integrity in normal cells. The nature of these mechanisms, and how their inactivation promotes carcinogenesis, remains enigmatic. I will review recent work from our laboratory on the tumour suppressor BRCA2 that addresses these issues, focusing on new insights into cancer pathogenesis and therapy that are emerging from improved understanding of the molecular basis of chromosomal instability in BRCA2-deficient cancer cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.