ArticleScientific reports2014
Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- In vivo screen reveals specific roles of Hippo pathway components in development and regeneration.Life science alliance · 2026Article
- The role of ATP-binding Cassette subfamily B member 6 in the inner ear.Nature communications · 2024Article
- Differentially expressed miRNA profiles of serum-derived exosomes in patients with sudden sensorineural hearing loss.Frontiers in neurology · 2023Article
- Toxicology evaluation of overdose hydroxychloroquine on zebrafish (Danio rerio) embryos.Scientific reports · 2022Article
- Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti.NPJ Regenerative medicine · 2022Article
- Hippo-Yap/Taz signalling in zebrafish regeneration.NPJ Regenerative medicine · 2022Review
- Dynamic patterns of YAP1 expression and cellular localization in the developing and injured utricle.Scientific reports · 2021Article
- Hair cell regeneration from inner ear progenitors in the mammalian cochlea.American journal of stem cells · 2020Review
- Open chromatin dynamics in prosensory cells of the embryonic mouse cochlea.Scientific reports · 2019Article
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- Lpar2b Controls Lateral Line Tissue Size by Regulating Yap1 Activity in Zebrafish.Frontiers in molecular neuroscience · 2018Article
- Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1.eLife · 2017Article
- Characterization of Lgr5+ Progenitor Cell Transcriptomes after Neomycin Injury in the Neonatal Mouse Cochlea.Frontiers in molecular neuroscience · 2017Article
- JNK Inhibition Inhibits Lateral Line Neuromast Hair Cell Development.Frontiers in cellular neuroscience · 2016Article
- The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish.Mechanisms of development · 2015Article
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- BDNF-TrkB axis regulates migration of the lateral line primordium and modulates the maintenance of mechanoreceptor progenitors.PloS one · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolutionarily conserved Hippo signaling pathway controls organ size by regulating cell proliferation and apoptosis and this process involves Yap1. The zebrafish Yap1 acts during neural differentiation, but its function is not fully understood. The detailed analysis of yap1 expression in proliferative regions, revealed it in the otic placode that gives rise to the lateral line system affected by the morpholino-mediated knockdown of Yap1. The comparative microarray analysis of transcriptome of Yap1-deficient embryos demonstrated changes in expression of many genes, including the Wnt signaling pathway and, in particular, prox1a known for its role in development of mechanoreceptors in the lateral line. The knockdown of Yap1 causes a deficiency of differentiation of mechanoreceptors, and this defect can be rescued by prox1a mRNA. Our studies revealed a role of Yap1 in regulation of Wnt signaling pathway and its target Prox1a during differentiation of mechanosensory cells.
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