Evidence map›Paper›PMID 24598708›Full record

ArticleNeurology2014

Restless legs syndrome status as a predictor for lower physical function.

Chunbai Zhang, Yanping Li, Atul Malhotra, Yi Ning, Xiang Gao

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Genetic evidence for a potential causal relationship between insomnia symptoms and suicidal behavior: a Mendelian randomization study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  5. Prevalence of Restless Legs Syndrome and Its Relationship with Fatigue in Critical Care Nurses.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021
    Article
  6. Article
  7. Article
  8. Sleep, Health and Wellness at Work: A Scoping Review.International journal of environmental research and public health · 2017
    Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chunbai ZhangFrom The Channing Division of Network Medicine (C.Z., Y.L., X.G.) and Division of Sleep Medicine (C.Z., A.M.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Department of Epidemiology and Community Health (Y.N.), Virginia Commonwealth University, Richmond; the Department of Nutrition (X.G.), Harvard School of Public Health, Boston, MA; and School of Public Health (XG), Peking Union Medical College, Beijing, China.
Yanping Li
Atul Malhotra
Yi Ning
Xiang Gao
Virginia Commonwealth University · USHarvard University · US

Funding

Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Prospective Study of Restless Leg SyndromeR01NS062879 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI GAO, XIANG · 2009 to 2011
$1.0M
Assessment of Upper Airway Mechanics Using Newer EMG TechniquesK24HL093218 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2009 to 2013
$857k
NCI NIH HHS R01 P01 CA055075NHLBI NIH HHS K24 HL093218NHLBI NIH HHS R01 HL085188NINDS NIH HHS 5R01NS062879-03
6 · The paper itself

Abstract

objectiveTo examine the potential long-term impact of restless legs syndrome (RLS) and other common sleep complaints on subsequent physical function (PF), we conducted a longitudinal analysis of 12,556 men in the Health Professionals Follow-up Study.

methodsWe used a set of questions recommended by the International RLS Study Group to assess RLS in 2002. We asked questions regarding other sleep complaints--insomnia, sleep fragmentation, and excessive daytime sleepiness--in 2004. We used the Physical Function (PF-10) survey of the Short Form-36 Health Survey to characterize PF in 1996 and 2008. We examined the 2008 PF-10 scores across categories of baseline RLS (2002), adjusted for age, 1996 PF-10 score, and other potential confounders.

resultsThe participants with RLS at baseline had significantly lower PF-10 score 6 years later than those without RLS (mean difference = -2.32, p = 0.01), after adjusting for potential confounders. The magnitude of difference in PF-10 score for RLS symptoms ≥ 15 times/month vs no RLS was more than that of a 5-year increase of age or moderate amount of smoking. Having daily daytime sleepiness and sleep duration ≥ 9 hours/day were associated with lower mean PF value than not having these symptoms (p < 0.05 for both).

conclusionsRLS and other sleep complaints are associated with lower PF. Our findings need to be replicated by more longitudinal studies including women and populations of other social and cultural backgrounds. It is important to understand whether RLS is an independent risk factor or a marker for other unknown risk factors for disability.

Indexed as

AdultAgedFollow-Up StudiesHealth SurveysHumansMaleMiddle AgedPredictive Value of TestsRestless Legs SyndromeRisk FactorsSleepSleep Initiation and Maintenance DisordersSurveys and Questionnaires

Identifiers

PMID24598708
PMCPMC4001206
OpenAlexW2165057172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.