ArticleJournal of neurophysiology2014
Genetic disruption of the On visual pathway affects cortical orientation selectivity and contrast sensitivity in mice.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Luminance Contrast Shifts Dominance Balance between ON and OFF Pathways in Human Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cortical mechanisms of visual brightness.Cell reports · 2022Article
- ON than OFF pathway disruption leads to greater deficits in visual function and retinal dopamine signaling.Experimental eye research · 2022Article
- How Cortical Circuits Implement Cortical Computations: Mouse Visual Cortex as a Model.Annual review of neuroscience · 2021Review
- Image luminance changes contrast sensitivity in visual cortex.Cell reports · 2021Article
- Lack of Evidence for Stereotypical Direction Columns in the Mouse Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Effects of Locomotion on Visual Responses in the Mouse Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Amblyopia Affects the ON Visual Pathway More than the OFF.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits.Neuron · 2018Article
- Article
- Searching for biomarkers of CDKL5 disorder: early-onset visual impairment in CDKL5 mutant mice.Human molecular genetics · 2017Article
- Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness.Human molecular genetics · 2015Article
- Neurons in the most superficial lamina of the mouse superior colliculus are highly selective for stimulus direction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Progressive degeneration of retinal and superior collicular functions in mice with sustained ocular hypertension.Investigative ophthalmology & visual science · 2015Article
- Voriconazole, an antifungal triazol that causes visual side effects, is an inhibitor of TRPM1 and TRPM3 channels.Investigative ophthalmology & visual science · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The retina signals stimulus contrast via parallel On and Off pathways and sends the information to higher visual centers. Here we study the role of the On pathway using mice that have null mutations in the On-specific GRM6 receptor in the retina (Pinto LH, Vitaterna MH, Shimomura K, Siepka SM, Balannik V, McDearmon EL, Omura C, Lumayag S, Invergo BM, Brandon M, Glawe B, Cantrell DR, Donald R, Inayat S, Olvera MA, Vessey KA, Kirstan A, McCall MA, Maddox D, Morgans CW, Young B, Pletcher MT, Mullins RF, Troy JB, Takahashi JS. Vis Neurosci 24: 111-123, 2007; Maddox DM, Vessey KA, Yarbrough GL, Invergo BM, Cantrell DR, Inayat S, Balannik V, Hicks WL, Hawes NL, Byers S, Smith RS, Hurd R, Howell D, Gregg RG, Chang B, Naggert JK, Troy JB, Pinto LH, Nishina PM, McCall MA. J Physiol 586: 4409-4424, 2008). In these "nob" mice, single unit recordings in the primary visual cortex (V1) reveal degraded selectivity for orientations due to an increased response at nonpreferred orientations. Contrast sensitivity in the nob mice is reduced with severe deficits at low contrast, consistent with the phenotype of night blindness in human patients with mutations in Grm6. These cortical deficits can be largely explained by reduced input drive and increased response variability seen in nob V1. Interestingly, increased variability is also observed in the superior colliculus of these mice but does not affect its tuning properties. Further, the increased response variability in the nob mice is traced to the retina, a result phenocopied by acute pharmacological blockade of the On pathway in wild-type retina. Together, our results suggest that the On and Off pathways normally interact to increase response reliability in the retina, which in turn propagates to various central visual targets and affects their functional properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.