ArticleJournal of neurophysiology2014
Oxygen and seizure dynamics: I. Experiments.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain.Epilepsia · 2026Article
- Neurodevelopmental disorder-causing GRIN1 Y647S variant alters red blood cell physiology in mice.Physiological reports · 2026Article
- Tissue Oxygenation Dynamics During Seizure to Spreading Depolarization in Rat Brain.bioRxiv : the preprint server for biology · 2025Article
- Proinflammatory factors inhibition and fish oil treatment: A promising therapy for neonatal seizures.IBRO neuroscience reports · 2024Article
- The Na+/K+-ATPase generically enables deterministic bursting in class I neurons by shearing the spike-onset bifurcation structure.PLoS computational biology · 2024Article
- Mechanisms underlying pathological cortical bursts during metabolic depletion.Nature communications · 2023Article
- Oxygenated Water Increases Seizure Threshold in Various Rodent Seizure Models.International journal of molecular sciences · 2022Article
- A model of metabolic supply-demand mismatch leading to secondary brain injury.Journal of neurophysiology · 2021Article
- Changes in the expression of endothelial monocyte‑activating polypeptide II in the rat hippocampus following status epilepticus.International journal of molecular medicine · 2021Article
- The Biochemical Profile of Post-Mortem Brain from People Who Suffered from Epilepsy Reveals Novel Insights into the Etiopathogenesis of the Disease.Metabolites · 2020Article
- Ionic and synaptic mechanisms of seizure generation and epileptogenesis.Neurobiology of disease · 2019Review
- Origin of slow spontaneous resting-state neuronal fluctuations in brain networks.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization.PLoS computational biology · 2017Article
- RNA SEQ Analysis Indicates that the AE3 ClScientific reports · 2017Article
- Glycolytic inhibition by 2-deoxy-d-glucose abolishes both neuronal and network bursts in an in vitro seizure model.Journal of neurophysiology · 2017Article
- Electroencephalographic Periodic Discharges and Frequency-Dependent Brain Tissue Hypoxia in Acute Brain Injury.JAMA neurology · 2017Article
- Interaction between synaptic inhibition and glial-potassium dynamics leads to diverse seizure transition modes in biophysical models of human focal seizures.Journal of computational neuroscience · 2016Article
- Dynamic transition of neuronal firing induced by abnormal astrocytic glutamate oscillation.Scientific reports · 2016Article
- Large extracellular space leads to neuronal susceptibility to ischemic injury in a Na+/K+ pumps-dependent manner.Journal of computational neuroscience · 2016Article
- Anions Govern Cell Volume: A Case Study of Relative Astrocytic and Neuronal Swelling in Spreading Depolarization.PloS one · 2016Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
We utilized a novel ratiometric nanoquantum dot fluorescence resonance energy transfer (NQD-FRET) optical sensor to quantitatively measure oxygen dynamics from single cell microdomains during hypoxic episodes as well as during 4-aminopyridine (4-AP)-induced spontaneous seizure-like events in rat hippocampal slices. Coupling oxygen sensing with electrical recordings, we found the greatest reduction in the O2 concentration ([O2]) in the densely packed cell body stratum (st.) pyramidale layer of the CA1 and differential layer-specific O2 dynamics between the st. pyramidale and st. oriens layers. These hypoxic decrements occurred up to several seconds before seizure onset could be electrically measured extracellularly. Without 4-AP, we quantified a narrow range of [O2], similar to the endogenous hypoxia found before epileptiform activity, which permits a quiescent network to enter into a seizure-like state. We demonstrated layer-specific patterns of O2 utilization accompanying layer-specific neuronal interplay in seizure. None of the oxygen overshoot artifacts seen with polarographic measurement techniques were observed. We therefore conclude that endogenously generated hypoxia may be more than just a consequence of increased cellular excitability but an influential and critical factor for orchestrating network dynamics associated with epileptiform activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.