ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2014
Methodological considerations for measuring spontaneous physical activity in rodents.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Exploring New Ways to Analyze Data on the Spontaneous Physical Activity of Rodents Through a Weighing Balance.Sensors (Basel, Switzerland) · 2025Article
- Therapeutic potential of orally applied KB-R7943 in streptozotocin-induced neuropathy in rats.Heliyon · 2024Article
- Modulation of foraging-like behaviors by cholesterol-FGF19 axis.Cell & bioscience · 2023Article
- Enlarged housing space and increased spatial complexity enhance hippocampal neurogenesis but do not increase physical activity in mice.Frontiers in sports and active living · 2023Article
- Ermin deficiency leads to compromised myelin, inflammatory milieu, and susceptibility to demyelinating insult.Brain pathology (Zurich, Switzerland) · 2022Article
- Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure.Behavioural brain research · 2022Article
- Cortical astrocytes regulate ethanol consumption and intoxication in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Method to Obtain Pattern of Breathing in Senescent Mice through Unrestrained Barometric Plethysmography.Journal of visualized experiments : JoVE · 2020Article
- Young and middle-aged mouse breathing behavior during the light and dark cycles.Physiological reports · 2019Article
- Article
- Spontaneous Physical Activity Defends Against Obesity.Current obesity reports · 2017Review
- Evaluation of Touchscreen Chambers To Assess Cognition in Adult Mice: Effect of Training and Mild Traumatic Brain Injury.Journal of neurotrauma · 2017Article
- Orexin signaling in rostral lateral hypothalamus and nucleus accumbens shell in the control of spontaneous physical activity in high- and low-activity rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Effect of Housing Types on Growth, Feeding, Physical Activity, and Anxiety-Like Behavior in Male Sprague-Dawley Rats.Frontiers in nutrition · 2016Article
- EEG Radiotelemetry in Small Laboratory Rodents: A Powerful State-of-the Art Approach in Neuropsychiatric, Neurodegenerative, and Epilepsy Research.Neural plasticity · 2016Review
- Physically active rats lose more weight during calorie restriction.Physiology & behavior · 2015Article
- Role of spontaneous physical activity in prediction of susceptibility to activity based anorexia in male and female rats.Physiology & behavior · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
When exploring biological determinants of spontaneous physical activity (SPA), it is critical to consider whether methodological factors differentially affect rodents and the measured SPA. We determined whether acclimation time, sensory stimulation, vendor, or chamber size affected measures in rodents with varying propensity for SPA. We used principal component analysis to determine which SPA components (ambulatory and vertical counts, time in SPA, and distance traveled) best described the variability in SPA measurements. We compared radiotelemetry and infrared photobeams used to measure SPA and exploratory activity. Acclimation time, sensory stimulation, vendor, and chamber size independently influenced SPA, and the effect was moderated by the propensity for SPA. A 24-h acclimation period prior to SPA measurement was sufficient for habituation. Principal component analysis showed that ambulatory and vertical measurements of SPA describe different dimensions of the rodent's SPA behavior. Smaller testing chambers and a sensory attenuation cubicle around the chamber reduced SPA. SPA varies between rodents purchased from different vendors. Radiotelemetry and infrared photobeams differ in their sensitivity to detect phenotypic differences in SPA and exploratory activity. These data highlight methodological considerations in rodent SPA measurement and a need to standardize SPA methodology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.