Trial reportFunctional neurology
Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study.
Trial report in Functional neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of non-pharmacological treatments for prolonged disorders of consciousness: a network meta-analysis of randomized controlled trials.Frontiers in neurologyPooled it
- Perturbational complexity index in assessing responsiveness to rTMS treatment in patients with disorders of consciousness: a cross-over randomized controlled trial study.Journal of neuroengineering and rehabilitation · 2024Trial
- Emergence From Minimally Conscious State Following Addition of Zolpidem to Amantadine Therapy in a Patient With Preserved Cortical Metabolism After Subarachnoid Hemorrhage: A Case Report.Brain & NeuroRehabilitation · 2026Article
- Thalamic sonication in chronic disorders of consciousness: a mechanistic single-arm clinical trial.medRxiv : the preprint server for health sciences · 2026Article
- Review
- Exploring the role of zolpidem in alleviating cognitive and motor impairments in chronic cerebral hypoperfusion: a rat model study with in vivo and in silico insights.Experimental animals · 2026Article
- Validation to Brazilian Portuguese of the coma recovery scale-revised.Arquivos de neuro-psiquiatria · 2024Article
- Article
- Treatment and Rehabilitation for Traumatic Brain Injury: Current Update.Brain & NeuroRehabilitation · 2022Review
- Pharmacologic Therapies to Promote Recovery of Consciousness.Seminars in neurology · 2022Article
- EEG Evidence Reveals Zolpidem-Related Alterations and Prognostic Value in Disorders of Consciousness.Frontiers in neuroscience · 2022Article
- The Outcome of Neurorehabilitation Efficacy and Management of Traumatic Brain Injury.Frontiers in human neuroscience · 2022Review
- Therapies to Restore Consciousness in Patients with Severe Brain Injuries: A Gap Analysis and Future Directions.Neurocritical care · 2021Article
- A Retrospective Analysis on Clinical Practice-Based Approaches Using Zolpidem and Lorazepam in Disorders of Consciousness.Brain sciences · 2021Article
- Paradoxical Motor and Cognitive Function Recovery in Response to Zolpidem in a Patient with Hypoxic-ischemic Brain Injury: A Case Report.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Article
- Neurorehabilitation of Traumatic Brain Injury (TBI): A Clinical Review.Medical sciences (Basel, Switzerland) · 2019Review
- The ethics of psychedelic research in disorders of consciousness.Neuroscience of consciousness · 2019Article
- Treating Disorders of Consciousness With Apomorphine: Protocol for a Double-Blind Randomized Controlled Trial Using Multimodal Assessments.Frontiers in neurology · 2019Article
- Effects of Cerebrolysin® in Patients With Minimally Conscious State After Stroke: An Observational Retrospective Clinical Study.Frontiers in neurology · 2019Article
- Deep brain stimulation for the treatment of disorders of consciousness and cognition in traumatic brain injury patients: a review.Neurosurgical focus · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zolpidem has been reported as an "awakening drug" in some patients with disorders of consciousness (DOC). We here present the results of a prospective openlabel study in chronic DOC patients. Sixty patients (35±15 years; 18 females; mean time since insult ± SD: 4±5.5 years; 31 with traumatic etiology) with a diagnosis of vegetative state/unresponsive wakefulness syndrome (n=28) or minimally conscious state (n=32) were behaviorally assessed using the Coma Recovery Scale-Revised (CRS-R) before and one hour after administration of 10 mg of zolpidem. At the group level, the diagnosis did not change after intake of zolpidem (p=0.10) and CRS-R total scores decreased (p=0.01). Twelve patients (20%) showed improved behaviors and/or CRS-R total scores after zolpidem administration but in only one patient was the diagnosis after zolpidem intake found to show a significant improvement (functional object use), which suggested a change of diagnosis. However, in this patient, a double-blind placebo-controlled trial was performed in order to better specify the effects of zolpidem, but the patient, on this trial, failed to show any clinical improvements. The present open-label study therefore failed to show any clinically significant improvement (i.e., change of Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study diagnosis) in any of the 60 studied chronic DOC patients.
Indexed as
Identifiers
24598393PMC3951253What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.