ArticleBehavioural brain research2015
An integrative analysis of ethanol tolerance and withdrawal in zebrafish (Danio rerio).
Article in Behavioural brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Lippia grata Schauer: Essential Oil as a Source of the Phytotherapeutic Thymol for the Treatment of Seizures and Anxiety Induced by Alcohol Withdrawal in Adult Zebrafish.Chemistry & biodiversity · 2026Article
- Behavioral impact of condensed repeated ethanol dosing on withdrawal in adult zebrafish (Frontiers in systems neuroscience · 2026Article
- Evaluation of the Sedative Effect of Limonene to Reduce Stress During Transportation of Gilthead Seabream (Biology · 2025Article
- Advances in Zebrafish as a Comprehensive Model of Mental Disorders.Depression and anxiety · 2023Review
- Acute Administration of Ethanol and of a D1-Receptor Antagonist Affects the Behavior and Neurochemistry of Adult Zebrafish.Biomedicines · 2022Article
- Maternal Chronic Ethanol Exposure Decreases Stress Responses in Zebrafish Offspring.Biomolecules · 2022Article
- Article
- Conservation of mechanisms regulating emotional-like responses on spontaneous nicotine withdrawal in zebrafish and mammals.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- The importance of individual variation for the interpretation of behavioural studies: ethanol effects vary with basal activity level in zebrafish larvae.Psychopharmacology · 2021Article
- Ethanol affects behavior and HPA axis activity during development in zebrafish larvae.Scientific reports · 2020Article
- Repeated ethanol exposure increases anxiety-like behaviour in zebrafish during withdrawal.PeerJ · 2019Article
- Adult zebrafish in CNS disease modeling: a tank that's half-full, not half-empty, and still filling.Lab animal · 2017Article
- Zebrafish models in neuropsychopharmacology and CNS drug discovery.British journal of pharmacology · 2017Review
- Resilience assessment of a biological early warning system based on the locomotor behavior of zebrafish (Danio rerio).Environmental science and pollution research international · 2016Article
- Alcohol-induced behavioral changes in zebrafish: The role of dopamine D2-like receptors.Psychopharmacology · 2016Article
- Concentration, population, and context-dependent effects of AM251 in zebrafish.Psychopharmacology · 2016Article
- Inhibition of phosphorylated tyrosine hydroxylase attenuates ethanol-induced hyperactivity in adult zebrafish (Danio rerio).Pharmacology, biochemistry, and behavior · 2015Article
- Differential effects of acute administration of SCH-23390, a D₁ receptor antagonist, and of ethanol on swimming activity, anxiety-related responses, and neurochemistry of zebrafish.Psychopharmacology · 2015Article
- Acute and chronic alcohol administration: effects on performance of zebrafish in a latent learning task.Behavioural brain research · 2015Article
- Molecular psychiatry of zebrafish.Molecular psychiatry · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The zebrafish is emerging as a popular animal model for alcohol (ethanol or EtOH) addiction due to its simplicity and practical advantages. Two phenomena associated with ethanol addiction are the development of tolerance and withdrawal. Using a multi-level approach in the current study, we characterise ethanol tolerance and withdrawal in zebrafish. We first investigate the temporal trajectory of ethanol concentration in the zebrafish brain in response to an acute exposure and during withdrawal. We report that ethanol concentrations approach a steady state within 60 min of exposure to 0.50% and 1.00% v/v ethanol and rapidly decline and return to zero within 60 min following withdrawal from chronic ethanol exposure (0.50% v/v). We characterise the changes associated with ethanol tolerance and withdrawal in zebrafish by focusing on three domains relevant to ethanol addiction: motor patterns, physiological responses (i.e. cortisol levels), and neurochemical alterations. The use of multiple domains of investigation allowed an in-depth analysis of ethanol induced changes in zebrafish.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.