ReviewEpidemiology and infection2014
A review of invasive Haemophilus influenzae disease in the Indigenous populations of North America.
Review in Epidemiology and infection, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Haemophilus influenzae Type b Vaccine Immunogenicity in American Indian/Alaska Native Infants.Pediatrics · 2024Trial
- Trial
- Clinical Course and Outcomes of Invasive Haemophilus influenzae Infections among Children at Two Hospitals in Alaska.The Journal of pediatrics · 2026Article
- Comparative analysis of blood routine, C-reactive protein, and biochemical markers in children withFrontiers in pediatrics · 2025Article
- Article
- Tolerance to Haemophilus influenzae infection in human epithelial cells: Insights from a primary cell-based model.PLoS pathogens · 2024Article
- Invasive and Non-invasive ClinicalPathogens & immunity · 2024Article
- Epidemiology of invasiveInternational journal of circumpolar health · 2022Article
- Phylogenetic Structure and Comparative Genomics of Multi-National InvasiveFrontiers in microbiology · 2022Article
- Long Term Impact of Conjugate Vaccines onMicroorganisms · 2021Review
- InvasiveOpen forum infectious diseases · 2020Article
- Mercury Exposure and Poor Nutritional Status Reduce Response to Six Expanded Program on Immunization Vaccines in Children: An Observational Cohort Study of Communities Affected by Gold Mining in the Peruvian Amazon.International journal of environmental research and public health · 2019Observational
- Current Epidemiology and Trends in Invasive Haemophilus influenzae Disease-United States, 2009-2015.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Vaccine-preventable, hospitalizations among American Indian/Alaska Native children using the 2012 Kid's Inpatient Database.Vaccine · 2018Article
- Insights on persistent airway infection by non-typeable Haemophilus influenzae in chronic obstructive pulmonary disease.Pathogens and disease · 2017Review
- The emergingCanada communicable disease report = Releve des maladies transmissibles au Canada · 2017Article
- First Complete Genome Sequence of Haemophilus influenzae Serotype a.Genome announcements · 2017Article
- Article
- Dynamics of naturally acquired antibody against Haemophilus influenzae type a capsular polysaccharide in a Canadian Aboriginal population.Preventive medicine reports · 2016Article
- Simulating Immune Interference on the Effect of a Bivalent Glycoconjugate Vaccine against Haemophilus influenzae Serotypes "a" and "b".The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Historically, the highest incidence rates of invasive Haemophilus influenzae disease in the world were found in North American and Australian Indigenous children. Although immunization against H. influenzae type b (Hib) led to a marked decrease in invasive Hib disease in countries where it was implemented, this disease has not been eliminated and its rates in Indigenous communities remain higher than in the general North American population. In this literature review, we examined the epidemiology of invasive H. influenzae disease in the pre-Hib vaccine era, effect of carriage on disease epidemiology, immune response to H. influenzae infection and Hib vaccination in Indigenous and Caucasian children, and the changing epidemiology after Hib conjugate vaccine has been in use for more than two decades in North America. We also explored reasons behind the continued high rates of invasive H. influenzae disease in Indigenous populations in North America. H. influenzae type a (Hia) has emerged as a significant cause of severe disease in North American Indigenous communities. More research is needed to define the genotypic diversity of Hia and the disease burden that it causes in order to determine if a Hia vaccine is required to protect the vulnerable populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.