ArticleJournal of the Royal Society, Interface2014
Mathematical modelling of adult hippocampal neurogenesis: effects of altered stem cell dynamics on cell counts and bromodeoxyuridine-labelled cells.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- In silico modeling of directed differentiation of induced pluripotent stem cells to definitive endoderm.PLoS computational biology · 2025Article
- Agile Mentorship: A Longitudinal Exploratory Analysis.ATS scholar · 2023Article
- Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population.Cell stem cell · 2021Article
- BCNNM: A Framework forFrontiers in computational neuroscience · 2020Article
- A multiscale mathematical model of cell dynamics during neurogenesis in the mouse cerebral cortex.BMC bioinformatics · 2019Article
- Mathematical Modeling of Cortical Neurogenesis Reveals that the Founder Population does not Necessarily Scale with Neurogenic Output.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Revealing age-related changes of adult hippocampal neurogenesis using mathematical models.Development (Cambridge, England) · 2018Article
- Modeling Reveals the Dependence of Hippocampal Neurogenesis Radiosensitivity on Age and Strain of Rats.Frontiers in neuroscience · 2018Article
- A simulation model of neuroprogenitor proliferation dynamics predicts age-related loss of hippocampal neurogenesis but not astrogenesis.Scientific reports · 2017Article
- Multitype Bellman-Harris branching model provides biological predictors of early stages of adult hippocampal neurogenesis.BMC systems biology · 2017Article
- Differential Roles of Environmental Enrichment in Alzheimer's Type of Neurodegeneration and Physiological Aging.Frontiers in aging neuroscience · 2017Article
- Modeling Heavy-Ion Impairment of Hippocampal Neurogenesis after Acute and Fractionated Irradiation.Radiation research · 2016Article
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3 authors.
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Abstract
In the adult hippocampus, neurogenesis-the process of generating mature granule cells from adult neural stem cells-occurs throughout the entire lifetime. In order to investigate the involved regulatory mechanisms, knockout (KO) experiments, which modify the dynamic behaviour of this process, were conducted in the past. Evaluating these KOs is a non-trivial task owing to the complicated nature of the hippocampal neurogenic niche. In this study, we model neurogenesis as a multicompartmental system of ordinary differential equations based on experimental data. To analyse the results of KO experiments, we investigate how changes of cell properties, reflected by model parameters, influence the dynamics of cell counts and of the experimentally observed counts of cells labelled by the cell division marker bromodeoxyuridine (BrdU). We find that changing cell proliferation rates or the fraction of self-renewal, reflecting the balance between symmetric and asymmetric cell divisions, may result in multiple time phases in the response of the system, such as an initial increase in cell counts followed by a decrease. Furthermore, these phases may be qualitatively different in cells at different differentiation stages and even between mitotically labelled cells and all cells existing in the system.
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